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Nicholson, G.* ; Rantalainen, M.* ; Li, J.V.* ; Maher, AD.* ; Malmodin, D.* ; Ahmadi, K.R.* ; Faber, J.H.* ; Barrett, A.* ; Min, J.L.* ; Rayner, N.W.* ; Toft, H.* ; Krestyaninova, M.* ; Viksna, J.* ; Neogi, S.G.* ; Dumas, M.E.* ; Sarkans, U* ; MolPAGE Consortium (*) ; Donnelly, P.* ; Illig, T. ; Adamski, J. ; Suhre, K. ; Allen, M.* ; Zondervan, K.T.* ; Spector, T.D.* ; Nicholson, J.K.* ; Lindon, J.C.* ; Baunsgaard, D.* ; Holmes, E.* ; McCarthy, M.I.* ; Holmes, C.C.*

A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

PLoS Genet. 7:e1002270 (2011)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
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We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of individuals of European descent, with one cohort comprised of female twins donating samples longitudinally. Sample metabolite concentrations were quantified by (1)H NMR and tested for association with genome-wide single-nucleotide polymorphisms (SNPs). Four metabolites' concentrations exhibited significant, replicable association with SNP variation (8.6×10(-11)
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Publication type Article: Journal article
Document type Scientific Article
Keywords no keywords
Language english
Publication Year 2011
HGF-reported in Year 2011
ISSN (print) / ISBN 1553-7390
e-ISSN 1553-7404
Journal PLoS Genetics
Quellenangaben Volume: 7, Issue: 9, Pages: , Article Number: e1002270 Supplement: ,
Publisher Public Library of Science (PLoS)
Reviewing status Peer reviewed
Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)
Research Unit Molecular Epidemiology (AME)
Institute of Bioinformatics and Systems Biology (IBIS)
POF-Topic(s) 30201 - Metabolic Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30505 - New Technologies for Biomedical Discoveries
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-505600-001
G-504200-003
G-503700-001
PubMed ID 21931564
DOI 10.1371/journal.pgen.1002270
Scopus ID 80053456207
Erfassungsdatum 2011-10-04
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