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Nicholson, G.* ; Rantalainen, M.* ; Li, J.V.* ; Maher, AD.* ; Malmodin, D.* ; Ahmadi, K.R.* ; Faber, J.H.* ; Barrett, A.* ; Min, J.L.* ; Rayner, N.W.* ; Toft, H.* ; Krestyaninova, M.* ; Viksna, J.* ; Neogi, S.G.* ; Dumas, M.E.* ; Sarkans, U* ; MolPAGE Consortium (*) ; Donnelly, P.* ; Illig, T. ; Adamski, J. ; Suhre, K. ; Allen, M.* ; Zondervan, K.T.* ; Spector, T.D.* ; Nicholson, J.K.* ; Lindon, J.C.* ; Baunsgaard, D.* ; Holmes, E.* ; McCarthy, M.I.* ; Holmes, C.C.*

A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.

PLoS Genet. 7:e1002270 (2011)
Publ. Version/Full Text Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
We have performed a metabolite quantitative trait locus (mQTL) study of the (1)H nuclear magnetic resonance spectroscopy ((1)H NMR) metabolome in humans, building on recent targeted knowledge of genetic drivers of metabolic regulation. Urine and plasma samples were collected from two cohorts of individuals of European descent, with one cohort comprised of female twins donating samples longitudinally. Sample metabolite concentrations were quantified by (1)H NMR and tested for association with genome-wide single-nucleotide polymorphisms (SNPs). Four metabolites' concentrations exhibited significant, replicable association with SNP variation (8.6×10(-11)
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords no keywords
ISSN (print) / ISBN 1553-7390
e-ISSN 1553-7404
Journal PLoS Genetics
Quellenangaben Volume: 7, Issue: 9, Pages: , Article Number: e1002270 Supplement: ,
Publisher Public Library of Science (PLoS)
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)
Research Unit Molecular Epidemiology (AME)
Institute of Bioinformatics and Systems Biology (IBIS)