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Camargo Ortega, G.* ; Götz, M.

Centrosome heterogeneity in stem cells regulates cell diversity.

Trends Cell Biol. 32, 707-719 (2022)
Postprint DOI PMC
Open Access Green
Stem cells are at the source of creating cellular diversity. Multiple mechanisms, including basic cell biological processes, regulate their fate. The centrosome is at the core of many stem cell functions and recent work highlights the association of distinct proteins at the centrosome in stem cell differentiation. As showcased by a novel centrosome protein regulating neural stem cell differentiation, it is timely to review the heterogeneity of the centrosome at protein and RNA levels and how this impacts their function in stem and progenitor cells. Together with evidence for heterogeneity of other organelles so far considered as similar between cells, we call for exploring the cell type-specific composition of organelles as a way to expand protein function in development with relevance to regenerative medicine.
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Publication type Article: Journal article
Document type Review
Keywords Centrosome ; Differentiation ; Microtubule Organization ; Migration ; Neurogenesis ; Organelle Heterogeneity
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0962-8924
e-ISSN 1879-3088
Quellenangaben Volume: 32, Issue: 8, Pages: 707-719 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Cambridge
Reviewing status Peer reviewed
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Stem Cell and Neuroscience
PSP Element(s) G-500800-001
Scopus ID 85133959886
PubMed ID 35750615
Erfassungsdatum 2022-07-08