PuSH - Publication Server of Helmholtz Zentrum München

Holzapfel, C.* ; Waldenberger, M. ; Lorkowski, S.* ; Daniel, H.*

Genetics and epigenetics in personalized nutrition: Evidence, expectations, and experiences.

Mol. Nutr. Food Res. 66:e2200077 (2022)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
With the presentation of the blueprint of the first human genome in 2001 and the advent of technologies for high-throughput genetic analysis, personalized nutrition (PN) becomes a new scientific field and the first commercial offerings of genotype-based nutrition advice emerge at the same time. Here, the state of evidence for the effect of genetic and epigenetic factors in the development of obesity, the metabolic syndrome, and resulting illnesses such as non-insulin-dependent diabetes mellitus and cardiovascular diseases is summarized. This study also critically value the concepts of PN that are built around the new genetic avenue from both the academic and a commercial perspective and their effectiveness in causing sustained changes in diet, lifestyle, and for improving health. Despite almost 20 years of research and commercial direct-to-consumer offerings, evidence for the success of gene-based dietary recommendations is still generally lacking. This calls for new concepts of future PN solutions that incorporate more phenotypic measures and provide a panel of instruments (e.g., self- and bio-monitoring tools, feedback systems, algorithms based on artificial intelligence) that increases compliance based on the individual´s physical and social environment and value system.
Altmetric
Additional Metrics?
Edit extra informations Login
Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Cardiovascular Diseases ; Diabetes ; Methylation ; Obesity ; Single Nucleotide Polymorphism
ISSN (print) / ISBN 1613-4125
e-ISSN 1613-4133
Quellenangaben Volume: 66, Issue: 17, Pages: , Article Number: e2200077 Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Grants Federal Ministry of Education & Research (BMBF)