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An overview of the latest metabolomics studies on atopic eczema with new directions for study.
Int. J. Mol. Sci. 23:8791 (2022)
Atopic eczema (AE) is an inflammatory skin disorder affecting approximately 20% of children worldwide and early onset can lead to asthma and allergies. Currently, the mechanisms of the disease are not fully understood. Metabolomics, the analysis of small molecules in the skin produced by the host and microbes, opens a window to observe the mechanisms of the disease which then may lead to new drug targets for AE treatment. Here, we review the latest advances in AE metabolomics, highlighting both the lipid and non-lipid molecules, along with reviewing the metabolites currently known to reside in the skin.
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Publication type
Article: Journal article
Document type
Review
Keywords
Atopic Eczema ; Atopic Dermatitis ; Dermatitis ; Metabolomics ; Skin ; Lipidomics
ISSN (print) / ISBN
1422-0067
e-ISSN
1661-6596
Quellenangaben
Volume: 23,
Issue: 15,
Article Number: 8791
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit BioGeoChemistry and Analytics (BGC)
Institute of Environmental Medicine (IEM)
Institute of Environmental Medicine (IEM)
Grants
Center for Allergy Research and Education
Helmholtz Association
International Visegrad Fund
Christine Kühne – Center for Allergy Research and Education
Helmholtz Association
International Visegrad Fund
Christine Kühne – Center for Allergy Research and Education