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Kullmann, S. ; Veit, R. ; Crabtree, D.R.* ; Buosi, W.* ; Androutsos, O.* ; Johnstone, A.M.* ; Manios, Y.* ; Preissl, H. ; Smeets, P.A.M.*

The effect of hunger state on hypothalamic functional connectivity in response to food cues.

Hum. Brain Mapp. 44, 418-428 (2023)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The neural underpinnings of the integration of internal and external cues that reflect nutritional status are poorly understood in humans. The hypothalamus is a key integrative area involved in short- and long-term energy intake regulation. Hence, we examined the effect of hunger state on the hypothalamus network using functional magnetic resonance imaging. In a multicenter study, participants performed a food cue viewing task either fasted or sated on two separate days. We evaluated hypothalamic functional connectivity (FC) using psychophysiological interactions during high versus low caloric food cue viewing in 107 adults (divided into four groups based on age and body mass index [BMI]; age range 24-76 years; BMI range 19.5-41.5 kg/m2 ). In the sated compared to the fasted condition, the hypothalamus showed significantly higher FC with the bilateral caudate, the left insula and parts of the left inferior frontal cortex. Interestingly, we observed a significant interaction between hunger state and BMI group in the dorsolateral prefrontal cortex (DLPFC). Participants with normal weight compared to overweight and obesity showed higher FC between the hypothalamus and DLPFC in the fasted condition. The current study showed that task-based FC of the hypothalamus can be modulated by internal (hunger state) and external cues (i.e., food cues with varying caloric content) with a general enhanced communication in the sated state and obesity-associated differences in hypothalamus to DLPFC communication. This could potentially promote overeating in persons with obesity.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Fmri ; Food Cue Reactivity ; Functional Connectivity ; Hunger ; Insulin Resistance ; Obesity ; Satiety
ISSN (print) / ISBN 1065-9471
e-ISSN 1097-0193
Journal Human Brain Mapping
Quellenangaben Volume: 44, Issue: 2, Pages: 418-428 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants German Center for Diabetes Research
Federal Ministry of Education and Research
European Union Seventh Framework Programme