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Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity.
Front. Immunol. 13:889836 (2022)
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Coronavirus ; Covid-19 ; Multiplex Serology ; Nucleocapsid Protein ; Sars-cov-2
ISSN (print) / ISBN
1664-3224
e-ISSN
1664-3224
Journal
Frontiers in Immunology
Quellenangaben
Volume: 13,
Article Number: 889836
Publisher
Frontiers
Non-patent literature
Publications
Reviewing status
Peer reviewed