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Insights from multi-omics integration in complex disease primary tissues.
Trends Genet. 39, 46-58 (2023)
Genome-wide association studies (GWAS) have provided insights into the genetic basis of complex diseases. In the next step, integrative multi-omics approaches can characterize molecular profiles in relevant primary tissues to reveal the mechanisms that underlie disease development. Here, we highlight recent progress in four examples of complex diseases generated by integrative studies: type 2 diabetes (T2D), osteoarthritis, Alzheimer's disease (AD), and systemic lupus erythematosus (SLE). High-resolution methodologies such as single-cell and spatial omics techniques will become even more important in the future. Furthermore, we emphasize the urgent need to include as yet understudied cell types and increase the diversity of studied populations.
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Publication type
Article: Journal article
Document type
Review
Keywords
Alzheimer's Disease ; Multi-omics ; Osteoarthritis ; Primary Tissue ; Systemic Lupus Erythematosus ; Type 2 Diabetes; Systemic-lupus-erythematosus; Genome-wide Association; Alzheimers-disease; Osteoarthritis; Susceptibility
ISSN (print) / ISBN
0168-9479
Journal
Trends in Genetics
Quellenangaben
Volume: 39,
Issue: 1,
Pages: 46-58
Publisher
Elsevier
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Translational Genomics (ITG)