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Salehi, R. ; Sadafi, A. ; Gruber, A. ; Lienemann, P. ; Navab, N.* ; Albarqouni, S. ; Marr, C.

Unsupervised cross-domain feature extraction for single blood cell image classification.

Lect. Notes Comput. Sc. 13433 LNCS, 739-748 (2022)
Postprint DOI
Open Access Green
Diagnosing hematological malignancies requires identification and classification of white blood cells in peripheral blood smears. Domain shifts caused by different lab procedures, staining, illumination, and microscope settings hamper the re-usability of recently developed machine learning methods on data collected from different sites. Here, we propose a cross-domain adapted autoencoder to extract features in an unsupervised manner on three different datasets of single white blood cells scanned from peripheral blood smears. The autoencoder is based on an R-CNN architecture allowing it to focus on the relevant white blood cell and eliminate artifacts in the image. To evaluate the quality of the extracted features we use a simple random forest to classify single cells. We show that thanks to the rich features extracted by the autoencoder trained on only one of the datasets, the random forest classifier performs satisfactorily on the unseen datasets, and outperforms published oracle networks in the cross-domain task. Our results suggest the possibility of employing this unsupervised approach in more complicated diagnosis and prognosis tasks without the need to add expensive expert labels to unseen data.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Autoencoders ; Domain Adaptation ; Feature Extraction ; Microscopy ; Single Cell Classification ; Unsupervised Learning
ISSN (print) / ISBN 0302-9743
e-ISSN 1611-3349
Conference Title Medical Image Computing and Computer Assisted Intervention – MICCAI 2022
Journal Lecture Notes in Computer Science
Quellenangaben Volume: 13433 LNCS, Issue: , Pages: 739-748 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin [u.a.]
Non-patent literature Publications
Institute(s) Institute of AI for Health (AIH)
Helmholtz Artifical Intelligence Cooperation Unit (HAICU)