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Andersen, Z.J.* ; Zhang, J.* ; Jørgensen, J.T.* ; Samoli, E.* ; Liu, S.* ; Chen, J.* ; Strak, M.* ; Wolf, K. ; Weinmayr, G.* ; Rodopolou, S.* ; Remfry, E.* ; de Hoogh, K.* ; Bellander, T.* ; Brandt, J.* ; Concin, H.* ; Zitt, E.* ; Fecht, D.* ; Forastiere, F.* ; Gulliver, J.* ; Hoffmann, B.* ; Hvidtfeldt, U.A.* ; Monique Verschuren, W.M.* ; Jöckel, K.H.* ; So, R.* ; Cole-Hunter, T.* ; Mehta, A.J.* ; Mortensen, L.H.* ; Ketzel, M.* ; Lager, A.* ; Leander, K.* ; Ljungman, P.* ; Severi, G.* ; Boutron-Ruault, M.C.* ; Magnusson, P.K.E.* ; Nagel, G.* ; Pershagen, G.* ; Peters, A. ; Rizzuto, D.* ; van der Schouw, Y.T.* ; Schramm, S.* ; Stafoggia, M.* ; Katsouyanni, K.* ; Brunekreef, B.* ; Hoek, G.* ; Lim, Y.H.*

Long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in a large pooled European cohort: ELAPSE study.

Environ. Int. 170:107581 (2022)
Postprint Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Ambient air pollution is an established risk factor for premature mortality from chronic cardiovascular, respiratory and metabolic diseases, while evidence on neurodegenerative diseases and psychiatric disorders remains limited. We examined the association between long-term exposure to air pollution and mortality from dementia, psychiatric disorders, and suicide in seven European cohorts. Within the multicenter project ‘Effects of Low-Level Air Pollution: A Study in Europe’ (ELAPSE), we pooled data from seven European cohorts from six countries. Based on the residential addresses, annual mean levels of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC), ozone (O3), and 8 PM2.5 components were estimated using Europe-wide hybrid land-use regression models. We applied stratified Cox proportional hazard models to investigate the associations between air pollution and mortality from dementia, psychiatric disorders, and suicide. Of 271,720 participants, 900 died from dementia, 241 from psychiatric disorders, and 164 from suicide, during a mean follow-up of 19.7 years. In fully adjusted models, we observed positive associations of NO2 (hazard ratio [HR] = 1.38; 95 % confidence interval [CI]: 1.13, 1.70 per 10 µg/m3), PM2.5 (HR = 1.29; 95 % CI: 0.98, 1.71 per 5 µg/m3), and BC (HR = 1.37; 95 % CI: 1.11, 1.69 per 0.5 × 10−5/m) with psychiatric disorders mortality, as well as with suicide (NO2: HR = 1.13 [95 % CI: 0.92, 1.38]; PM2.5: HR = 1.19 [95 % CI: 0.76, 1.87]; BC: HR = 1.08 [95 % CI: 0.87, 1.35]), and no association with dementia mortality. We did not detect any positive associations of O3 and 8 PM2.5 components with any of the three mortality outcomes. Long-term exposure to NO2, PM2.5, and BC may lead to premature mortality from psychiatric disorders and suicide.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Air Pollution ; Dementia ; Long-term Exposure ; Mortality ; Psychiatric Disorders ; Suicide; ELAPSE, Gesundheitseffekte von Luftschadstoffen, mental health
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Journal Environment International
Quellenangaben Volume: 170, Issue: , Pages: , Article Number: 107581 Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)
Grants Deutsches Forschungszentrum für Gesundheit und Umwelt, Helmholtz Zentrum München
Novo Nordisk Fonden
China Scholarship Council
Vetenskapsrådet
Karolinska Institutet
Bundesministerium für Bildung und Forschung
Health Effects Institute
u.s. environmental protection agency
Novo Nordisk Foundation Challenge Programme