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Ito-Kureha, T.* ; Heissmeyer, V.

Critical functions of N6-adenosine methylation of mRNAs in T cells.

Biochim. Biophys. Acta-Mol. Cell Res. 1870:119380 (2023)
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The existence of N6-adenosine methylation (m6A) of mRNA has been known for a long time, but only recently its regulatory potential was uncovered. Current research deciphers the molecular determinants leading to the deposition of this modification and consequences for modified mRNAs. It also evaluates the importance of such modifications for specific cell types and programs. In this review, we summarize the current knowledge on m6A modification of mRNAs in conventional and regulatory T cells and T-cell-driven immune responses and pathology. We discuss the impact of m6A modification on T cell activation including cytokine and antigen receptor signaling or sensing of double-stranded RNAs (dsRNA).
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Publication type Article: Journal article
Document type Review
Keywords Epitranscriptomics ; M6a ; T Cell ; Tcr Signaling
Language english
Publication Year 2023
Prepublished in Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0167-4889
e-ISSN 1879-2596
Journal Biochimica et Biophysica Acta - Molecular Cell Research
Quellenangaben Volume: 1870, Issue: 1, Pages: , Article Number: 119380 Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Research Unit Molecular Immune Regulation (AMIR)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-501712-001
Grants Deutsche Forschungsgemeinschaft
DOI 10.1016/j.bbamcr.2022.119380
WOS ID WOS:000874822600003
Scopus ID 85139833640
PubMed ID 36228837
Erfassungsdatum 2022-11-25
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