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Associations of GHR, IGF-1 and IGFBP-3 expression in adipose tissue cells with obesity-related alterations in corresponding circulating levels and adipose tissue function in children.
Adipocyte 11, 630-642 (2022)
Components of the growth hormone (GH) axis, such as insulin-like growth factor-1 (IGF-1), IGF-1 binding protein-3 (IGFBP-3), GH receptor (GHR) and GH-binding protein (GHBP), regulate growth and metabolic pathways. Here, we asked if serum levels of these factors are altered with overweight/obesity and if this is related to adipose tissue (AT) expression and/or increased fat mass. Furthermore, we hypothesized that expression of GHR, IGF-1 and IGFBP-3 is associated with AT function. Serum GHBP levels were increased in children with overweight/obesity throughout childhood, while for IGF-1 levels and the IGF-1/IGFBP-3 molar ratio obesity-related elevations were detectable until early puberty. Circulating levels did not correlate with AT expression of these factors, which was decreased with overweight/obesity. Independent from obesity, expression of GHR, IGF-1 and IGFBP-3 was related to AT dysfunction,and increased insulin levels. Serum GHBP was associated with liver fat percentage and transaminase levels. We conclude that obesity-related elevations in serum GHBP and IGF-1 are unlikely to be caused by increased AT mass and elevations in GHBP are more closely related to liver status in children. The diminished AT expression of these factors with childhood obesity may contribute to early AT dysfunction and a deterioration of the metabolic state.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Adipose Tissue ; Childhood Obesity ; Children ; Ghbp ; Ghr ; Growth Hormone ; Igf-1 ; Igfbp-3 ; Liver Fat ; Obesity
ISSN (print) / ISBN
2162-3945
e-ISSN
2162-397X
Journal
Adipocyte
Quellenangaben
Volume: 11,
Issue: 1,
Pages: 630-642
Publisher
Landes Bioscience
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
Bundesministerium für Bildung und Forschung
Deutsche Forschungsgemeinschaft
European Society for Paediatric Endocrinology
Integrated Research and Treatment Center Adiposity Diseases
German Diabetes Association
Deutsche Forschungsgemeinschaft
European Society for Paediatric Endocrinology
Integrated Research and Treatment Center Adiposity Diseases
German Diabetes Association