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Smith, J.A.B.* ; Murach, K.A.* ; Dyar, K.A. ; Zierath, J.R.*

Exercise metabolism and adaptation in skeletal muscle.

Nat. Rev. Mol. Cell Biol. 24, 607-632 (2023)
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Viewing metabolism through the lens of exercise biology has proven an accessible and practical strategy to gain new insights into local and systemic metabolic regulation. Recent methodological developments have advanced understanding of the central role of skeletal muscle in many exercise-associated health benefits and have uncovered the molecular underpinnings driving adaptive responses to training regimens. In this Review, we provide a contemporary view of the metabolic flexibility and functional plasticity of skeletal muscle in response to exercise. First, we provide background on the macrostructure and ultrastructure of skeletal muscle fibres, highlighting the current understanding of sarcomeric networks and mitochondrial subpopulations. Next, we discuss acute exercise skeletal muscle metabolism and the signalling, transcriptional and epigenetic regulation of adaptations to exercise training. We address knowledge gaps throughout and propose future directions for the field. This Review contextualizes recent research of skeletal muscle exercise metabolism, framing further advances and translation into practice.
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Publication type Article: Journal article
Document type Review
Keywords Activated Protein-kinase; Hormone-sensitive Lipase; Respiratory-chain Supercomplexes; Fatty-acid Transport; Glucose-uptake; Fiber-type; Dynamic Exercise; Induced Increase; Creatine-kinase; Cardiorespiratory Fitness
Language english
Publication Year 2023
HGF-reported in Year 2023
ISSN (print) / ISBN 1471-0072
e-ISSN 1471-0080
Journal Nature Reviews - Molecular Cell Biology
Quellenangaben Volume: 24, Issue: 9, Pages: 607-632 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502594-001
Grants
Novo Nordisk Foundation Center for Basic Metabolic Research at the University of Copenhagen
Swedish Research Council for Sport Science
Swedish Research Council (Vetenskapsradet)
Deutsches Zentrum fur Diabetesforschung
National Institutes of Health
DOI 10.1038/s41580-023-00606-x
WOS ID 000994079000001
Scopus ID 85160233555
PubMed ID 37225892
Erfassungsdatum 2023-10-06
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