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Buschulte, K.* ; Kabitz, H.J.* ; Hagmeyer, L.* ; Hammerl, P.* ; Esselmann, A.* ; Wiederhold, C.* ; Skowasch, D.* ; Stolpe, C.* ; Joest, M.* ; Veitshans, S.* ; Höffgen, M.* ; Maqhuzu, P.N. ; Schwarzkopf, L. ; Hellmann, A.* ; Pfeifer, M.* ; Behr, J.* ; Karpavicius, R.* ; Günther, A.* ; Polke, M.* ; Höger, P.* ; Somogyi, V.* ; Lederer, C.W.* ; Markart, P.* ; Kreuter, M.*

Hospitalisation patterns in interstitial lung diseases: Data from the EXCITING-ILD registry.

Respir. Res. 25:5 (2024)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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BACKGROUND: Interstitial lung diseases (ILD) comprise a heterogeneous group of mainly chronic lung diseases with more than 200 entities and relevant differences in disease course and prognosis. Little data is available on hospitalisation patterns in ILD. METHODS: The EXCITING-ILD (Exploring Clinical and Epidemiological Characteristics of Interstitial Lung Diseases) registry was analysed for hospitalisations. Reasons for hospitalisation were classified as all cause, ILD-related and respiratory hospitalisations, and patients were analysed for frequency of hospitalisations, time to first non-elective hospitalisation, mortality and progression-free survival. Additionally, the risk for hospitalisation according to GAP index and ILD subtype was calculated by Cox proportional-hazard models as well as influencing factors on prediction of hospitalisation by logistic regression with forward selection. RESULTS: In total, 601 patients were included. 1210 hospitalisations were recorded during the 6 months prior to registry inclusion until the last study visit. 800 (66.1%) were ILD-related, 59.3% of admissions were registered in the first year after inclusion. Mortality was associated with all cause, ILD-related and respiratory-related hospitalisation. Risk factors for hospitalisation were advanced disease (GAP Index stages II and III) and CTD (connective tissue disease)-ILDs. All cause hospitalisations were associated with pulmonary hypertension (OR 2.53, p = 0.005). ILD-related hospitalisations were associated with unclassifiable ILD and concomitant emphysema (OR = 2.133, p = 0.001) as well as with other granulomatous ILDs and a positive smoking status (OR = 3.082, p = 0.005). CONCLUSION: Our results represent a crucial contribution in understanding predisposing factors for hospitalisation in ILD and its major impact on mortality. Further studies to characterize the most vulnerable patient group as well as approaches to prevent hospitalisations are warranted.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Hospitalisation ; Ild ; Ipf ; Prognosis ; Risk Factors; Idiopathic Pulmonary-fibrosis; Exacerbation; Update
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 1465-9921
e-ISSN 1465-993X
Journal Respiratory Research
Quellenangaben Volume: 25, Issue: 1, Pages: , Article Number: 5 Supplement: ,
Publisher BioMed Central
Publishing Place Campus, 4 Crinan St, London N1 9xw, England
Reviewing status Peer reviewed
Institute(s) Institute of Health Economics and Health Care Management (IGM)
POF-Topic(s) 80000 - German Center for Lung Research
30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-501800-533
G-505300-001
Grants Helmholtz Centre Munich
InterMune (now Roche)
DOI 10.1186/s12931-023-02588-y
WOS ID 001136836100011
Scopus ID 85181251411
PubMed ID 38178212
Erfassungsdatum 2024-01-07
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