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Xu, M.* ; Ho, V.* ; Lavoue, J.* ; Olsson, A.* ; Schüz, J.* ; Richardson, L.* ; Parent, M.E.* ; McLaughlin, J.R.* ; Demers, P.A.* ; Guénel, P.* ; Radoi, L.* ; Wichmann, H.-E. ; Ahrens, W.* ; Jöckel, K.H.* ; Consonni, D.* ; Landi, M.T.* ; Richiardi, L.* ; Simonato, L.* ; 't' Mannetje, A.* ; Świątkowska, B.* ; Field, J.K.* ; Pearce, N.* ; Siemiatycki, J.*

Prevalent occupational exposures and risk of lung cancer among women: Results from the application of the Canadian Job-Exposure Matrix (CANJEM) to a combined set of ten case–control studies.

Am. J. Ind. Med. 67, 200-213 (2024)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Background: Worldwide, lung cancer is the second leading cause of cancer death in women. The present study explored associations between occupational exposures that are prevalent among women, and lung cancer. Methods: Data from 10 case–control studies of lung cancer from Europe, Canada, and New Zealand conducted between 1988 and 2008 were combined. Lifetime occupational history and information on nonoccupational factors including smoking were available for 3040 incident lung cancer cases and 4187 controls. We linked each reported job to the Canadian Job-Exposure Matrix (CANJEM), which provided estimates of probability, intensity, and frequency of exposure to each selected agent in each job. For this analysis, we selected 15 agents (cleaning agents, biocides, cotton dust, synthetic fibers, formaldehyde, cooking fumes, organic solvents, cellulose, polycyclic aromatic hydrocarbons from petroleum, ammonia, metallic dust, alkanes C18+, iron compounds, isopropanol, and calcium carbonate) that had lifetime exposure prevalence of at least 5% in the combined study population. For each agent, we estimated lung cancer risk in each study center for ever-exposure, by duration of exposure, and by cumulative exposure, using separate logistic regression models adjusted for smoking and other covariates. We then estimated the meta-odds ratios using random-effects meta-analysis. Results and Conclusions: None of the agents assessed showed consistent and compelling associations with lung cancer among women. The following agents showed elevated odds ratio in some analyses: metallic dust, iron compounds, isopropanol, and organic solvents. Future research into occupational lung cancer risk factors among women should prioritize these agents.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Job-exposure Matrix ; Lung Cancer ; Metals ; Occupational Exposures ; Women; Postmenopausal Breast-cancer; Carcinogens; Environment; Men
ISSN (print) / ISBN 0271-3586
e-ISSN 1097-0274
Journal American Journal of Industrial Medicine
Quellenangaben Volume: 67, Issue: 3, Pages: 200-213 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Grants German Federal Ministry of Education, Science, Research, and Technology
Canadian Institutes for Health Research
Association for Research on Cancer (ARC)
Fondation de France
French Ministry of work, solidarity and public function (Direction Générale de la Santé)
French Ministry of Labour (Direction Générale du Travail)
Intramural Research Program of NIH, National Cancer Institute, Division of Cancer Epidemiology and Genetics and the Center for Cancer Research
Canadian Cancer Society
Fonds de Recherche du Québec - Santé
Agence Nationale de la Recherche
Institut de Recherche Robert-Sauvé en Santé et en Sécurité du Travail
Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail
French National Institute of Cancer (INCA)
Fondation pour la Recherche Medicale
Santé Publique France