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He, H. ; Paetzold, J.C.* ; Borner, N.* ; Riedel, E. ; Gerl, S.* ; Schneider, S.* ; Fisher, C. ; Ezhov, I.* ; Shit, S.* ; Li, H.* ; Rückert, D.* ; Aguirre, J.* ; Biedermann, T.* ; Darsow, U.* ; Menze, B.* ; Ntziachristos, V.

Machine learning analysis of human skin by optoacoustic mesoscopy for automated extraction of psoriasis and aging biomarkers.

IEEE Trans. Med. Imaging 43, 2074-2085 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Ultra-wideband raster-scan optoacoustic mesoscopy (RSOM) is a novel modality that has demonstrated unprecedented ability to visualize epidermal and dermal structures in-vivo. However, an automatic and quantitative analysis of three-dimensional RSOM datasets remains unexplored. In this work we present our framework: Deep Learning RSOM Analysis Pipeline (DeepRAP), to analyze and quantify morphological skin features recorded by RSOM and extract imaging biomarkers for disease characterization. DeepRAP uses a multi-network segmentation strategy based on convolutional neural networks with transfer learning. This strategy enabled the automatic recognition of skin layers and subsequent segmentation of dermal microvasculature with an accuracy equivalent to human assessment. DeepRAP was validated against manual segmentation on 25 psoriasis patients under treatment and our biomarker extraction was shown to characterize disease severity and progression well with a strong correlation to physician evaluation and histology. In a unique validation experiment, we applied DeepRAP in a time series sequence of occlusion-induced hyperemia from 10 healthy volunteers. We observe how the biomarkers decrease and recover during the occlusion and release process, demonstrating accurate performance and reproducibility of DeepRAP. Furthermore, we analyzed a cohort of 75 volunteers and defined a relationship between aging and microvascular features in-vivo. More precisely, this study revealed that fine microvascular features in the dermal layer have the strongest correlation to age. The ability of our newly developed framework to enable the rapid study of human skin morphology and microvasculature in-vivo promises to replace biopsy studies, increasing the translational potential of RSOM.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Biomarkers ; Feature Extraction ; Image Reconstruction ; Image Segmentation ; Imaging ; Machine Learning ; Morphology ; Optoacoustic Mesoscopy ; Photoacoustic ; Segmentation ; Skin ; Skin Aging ; Skin Imaging; Optical Coherence Tomography; Diagnosis
ISSN (print) / ISBN 0278-0062
e-ISSN 1558-254X
Journal IEEE Transactions on Medical Imaging
Quellenangaben Volume: 43, Issue: 6, Pages: 2074-2085 Article Number: , Supplement: ,
Publisher Institute of Electrical and Electronics Engineers (IEEE)
Publishing Place New York, NY [u.a.]
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Grants European Union's Horizon 2020 research and innovation programme