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Garcia Guerra, J.F. ; Matta Pereira, L. ; Bartelt, A.

Cardiac proteostasis in obesity and cardiovascular disease.

Kardiale Proteostase bei Adipositas und kardiovaskulären Erkrankungen.

Herz 49, 118-123 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Cardiovascular diseases (CVD) are closely linked to protein homeostasis (proteostasis) and its failure. Beside genetic mutations that impair cardiac protein quality control, obesity is a strong risk factor for heart disease. In obesity, adipose tissue becomes dysfunctional and impacts heart function and CVD progression by releasing cytokines that contribute to systemic insulin resistance and cardiovascular dysfunction. In addition, chronic inflammation and lipotoxicity compromise endoplasmic reticulum (ER) function, eliciting stress responses that overwhelm protein quality control beyond its capacity. Impairment of proteostasis-including dysfunction of the ubiquitin-proteasome system (UPS), autophagy, and the depletion of chaperones-is intricately linked to cardiomyocyte dysfunction. Interventions targeting UPS and autophagy pathways are new potential strategies for re-establishing protein homeostasis and improving heart function. Additionally, lifestyle modifications such as dietary interventions and exercise have been shown to promote cardiac proteostasis and overall metabolic health. The pursuit of future research dedicated to proteostasis and protein quality control represents a pioneering approach for enhancing cardiac health and addressing the complexities of obesity-related cardiac dysfunction.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Adipose Tissue ; Autophagy ; Endoplasmic Reticulum ; Heart Diseases ; Proteasome; Adipose-tissue; Nrf1; Cardiomyopathy; Enhancement; Inhibitor
ISSN (print) / ISBN 0340-9937
e-ISSN 1615-6692
Journal Herz
Quellenangaben Volume: 49, Issue: 2, Pages: 118-123 Article Number: , Supplement: ,
Publisher Springer
Publishing Place München
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
Grants European Research Training Group (ERC) Starting Grant PROTEOFIT
Deutsches Zentrum fur Herz-Kreislauf-Forschung (DZHK)
DFG