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Dai, E.* ; Chen, X.* ; Linkermann, A.* ; Jiang, X.* ; Kang, R.* ; Kagan, V.E.* ; Bayir, H.* ; Yang, W.S.* ; Garcia-Saez, A.J.* ; Ioannou, M.S.* ; Janowitz, T.* ; Ran, Q.* ; Gu, W.* ; Gan, B.* ; Krysko, D.V.* ; Zhu, X.* ; Wang, J.* ; Krautwald, S.* ; Toyokuni, S.* ; Xie, Y.* ; Greten, F.R.* ; Yi, Q.* ; Schick, J. ; Liu, J.* ; Gabrilovich, D.I.* ; Zeh, H.J.* ; Zhang, D.D.* ; Yang, M.* ; Iovanna, J.L.* ; Kopf, M.* ; Adolph, T.E.* ; Chi, J.T.* ; Li, C.* ; Ichijo, H.* ; Karin, M.* ; Sankaran, V.G.* ; Zou, W.* ; Galluzzi, L.* ; Bush, A.I.* ; Li, B.* ; Melino, G.* ; Baehrecke, E.H.* ; Lotze, M.T.* ; Klionsky, D.J.* ; Stockwell, B.R.* ; Kroemer, G.* ; Tang, D.*

A guideline on the molecular ecosystem regulating ferroptosis.

Nat. Cell Biol., DOI: 10.1038/s41556-024-01360-8 (2024)
DOI PMC
Open Access Green: Postprint online available 10/2024
Ferroptosis, an intricately regulated form of cell death characterized by uncontrolled lipid peroxidation, has garnered substantial interest since this term was first coined in 2012. Recent years have witnessed remarkable progress in elucidating the detailed molecular mechanisms that govern ferroptosis induction and defence, with particular emphasis on the roles of heterogeneity and plasticity. In this Review, we discuss the molecular ecosystem of ferroptosis, with implications that may inform and enable safe and effective therapeutic strategies across a broad spectrum of diseases.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Cell-death; Lipid-peroxidation; Promotes Ferroptosis; Cancer-cells; Gpx4; Protects; Stress; Susceptibility; Activation; Roles
ISSN (print) / ISBN 1465-7392
e-ISSN 1476-4679
Journal Nature Cell Biology
Publisher Nature Publishing Group
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Molecular Toxicology and Pharmacology (TOXI)
Grants US National Institutes of Health