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Maushagen, J. ; Addin, N.S. ; Schuppert, C.* ; Ward-Caviness, C.K.* ; Nattenmüller, J.* ; Adamski, J. ; Peters, A. ; Bamberg, F.* ; Schlett, C.L.* ; Wang-Sattler, R. ; Rospleszcz, S.

Serum metabolite signatures of cardiac function and morphology in individuals from a population-based cohort.

Biomark. Res. 12:31 (2024)
Publ. Version/Full Text DOI PMC
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BACKGROUND: Changes in serum metabolites in individuals with altered cardiac function and morphology may exhibit information about cardiovascular disease (CVD) pathway dysregulations and potential CVD risk factors. We aimed to explore associations of cardiac function and morphology, evaluated using magnetic resonance imaging (MRI) with a large panel of serum metabolites. METHODS: Cross-sectional data from CVD-free individuals from the population-based KORA cohort were analyzed. Associations between 3T-MRI-derived left ventricular (LV) function and morphology parameters (e.g., volumes, filling rates, wall thickness) and markers of carotid plaque with metabolite profile clusters and single metabolites as outcomes were assessed by adjusted multinomial logistic regression and linear regression models. RESULTS: In 360 individuals (mean age 56.3 years; 41.9% female), 146 serum metabolites clustered into three distinct profiles that reflected high-, intermediate- and low-CVD risk. Higher stroke volume (relative risk ratio (RRR): 0.53, 95%-CI [0.37; 0.76], p-value < 0.001) and early diastolic filling rate (RRR: 0.51, 95%-CI [0.37; 0.71], p-value < 0.001) were most strongly protectively associated against the high-risk profile compared to the low-risk profile after adjusting for traditional CVD risk factors. Moreover, imaging markers were associated with 10 metabolites in linear regression. Notably, negative associations of stroke volume and early diastolic filling rate with acylcarnitine C5, and positive association of function parameters with lysophosphatidylcholines, diacylphosphatidylcholines, and acylalkylphosphatidylcholines were observed. Furthermore, there was a negative association of LV wall thickness with alanine, creatinine, and symmetric dimethylarginine. We found no significant associations with carotid plaque. CONCLUSIONS: Serum metabolite signatures are associated with cardiac function and morphology even in individuals without a clinical indication of CVD.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cardiac Function ; Cardiac Morphology ; Cardiovascular Disease ; Imaging ; Left Ventricle ; Metabolites ; Population-based; Ventricular Diastolic Function; Heart-failure; Disease; Risk; Metabolomics; Association; Profile; Acylcarnitines; Metaboanalyst; Nomenclature
e-ISSN 2050-7771
Journal Biomarker Research
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 31 Supplement: ,
Publisher BMC
Publishing Place London
Non-patent literature Publications
Institute(s) Institute of Epidemiology II (EPI2)
Institute of Experimental Genetics (IEG)
Institute of Translational Genomics (ITG)
Grants Helmholtz Zentrum Mnchen - Deutsches Forschungszentrum fr Gesundheit und Umwelt (GmbH) (4209)