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Edge-illumination spectral phase-contrast tomography.
Phys. Med. Biol. 69:075027 (2024)
Following the rapid, but independent, diffusion of X-ray spectral and phase-contrast systems, this work demonstrates the first combination of spectral and phase-contrast computed tomography (CT) obtained by using the edge-illumination technique and a CdTe small-pixel (62 μm) spectral detector. A theoretical model is introduced, starting from a standard attenuation-based spectral decomposition and leading to spectral phase-contrast material decomposition. Each step of the model is followed by quantification of accuracy and sensitivity on experimental data of a test phantom containing different solutions with known concentrations. An example of a micro CT application (20 μm voxel size) on an iodine-perfusedex-vivomurine model is reported.
The work demonstrates that spectral-phase contrast combines the advantages of spectral imaging, i.e. high-Z material discrimination capability, and phase-contrast imaging, i.e. soft tissue sensitivity, yielding simultaneously mass density maps of water, calcium, and iodine with an accuracy of 1.1%, 3.5%, and 1.9% (root mean square errors), respectively. Results also show a 9-fold increase in the signal-to-noise ratio of the water channel when compared to standard spectral decomposition. The application to the murine model revealed the potential of the technique in the simultaneous 3D visualization of soft tissue, bone, and vasculature. While being implemented by using a broad spectrum (pink beam) at a synchrotron radiation facility (Elettra, Trieste, Italy), the proposed experimental setup can be readily translated to compact laboratory systems including conventional X-ray tubes.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Edge Illumination ; Photon-counting Detector ; Spectral Imaging ; X-ray Phase-contrast Imaging ; X-ray Tomography; Dual-energy Ct; Micro-ct; Ray; Decomposition
ISSN (print) / ISBN
0031-9155
e-ISSN
1361-6560
Journal
Physics in Medicine and Biology
Quellenangaben
Volume: 69,
Issue: 7,
Article Number: 075027
Publisher
Institute of Physics Publishing (IOP)
Publishing Place
Bristol
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Pioneer Campus (HPC)
Grants
Royal Academy of Engineering
Wellcome Trust
EPSRC
European Union - Next Generation EU
National Scientific Commission 5 for Technological and Inter-disciplinary Research
Italian National Institute for Nuclear Physics (INFN)
Royal Academy of Engineeringhttps://doi.org/10.13039/501100000287
Wellcome Trust
EPSRC
European Union - Next Generation EU
National Scientific Commission 5 for Technological and Inter-disciplinary Research
Italian National Institute for Nuclear Physics (INFN)
Royal Academy of Engineeringhttps://doi.org/10.13039/501100000287