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Brombal, L.* ; Arfelli, F.* ; Brun, F.* ; Di Trapani, V.* ; Endrizzi, M.* ; Menk, R.* ; Perion, P.* ; Rigon, L.* ; Saccomano, M. ; Tromba, G.* ; Olivo, A.*

Edge-illumination spectral phase-contrast tomography.

Phys. Med. Biol. 69:075027 (2024)
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Following the rapid, but independent, diffusion of X-ray spectral and phase-contrast systems, this work demonstrates the first combination of spectral and phase-contrast computed tomography (CT) obtained by using the edge-illumination technique and a CdTe small-pixel (62 μm) spectral detector. A theoretical model is introduced, starting from a standard attenuation-based spectral decomposition and leading to spectral phase-contrast material decomposition. Each step of the model is followed by quantification of accuracy and sensitivity on experimental data of a test phantom containing different solutions with known concentrations. An example of a micro CT application (20 μm voxel size) on an iodine-perfusedex-vivomurine model is reported. The work demonstrates that spectral-phase contrast combines the advantages of spectral imaging, i.e. high-Z material discrimination capability, and phase-contrast imaging, i.e. soft tissue sensitivity, yielding simultaneously mass density maps of water, calcium, and iodine with an accuracy of 1.1%, 3.5%, and 1.9% (root mean square errors), respectively. Results also show a 9-fold increase in the signal-to-noise ratio of the water channel when compared to standard spectral decomposition. The application to the murine model revealed the potential of the technique in the simultaneous 3D visualization of soft tissue, bone, and vasculature. While being implemented by using a broad spectrum (pink beam) at a synchrotron radiation facility (Elettra, Trieste, Italy), the proposed experimental setup can be readily translated to compact laboratory systems including conventional X-ray tubes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Edge Illumination ; Photon-counting Detector ; Spectral Imaging ; X-ray Phase-contrast Imaging ; X-ray Tomography; Dual-energy Ct; Micro-ct; Ray; Decomposition
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 0031-9155
e-ISSN 1361-6560
Journal Physics in Medicine and Biology
Quellenangaben Volume: 69, Issue: 7, Pages: , Article Number: 075027 Supplement: ,
Publisher Institute of Physics Publishing (IOP)
Publishing Place Bristol
Reviewing status Peer reviewed
Institute(s) Helmholtz Pioneer Campus (HPC)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Pioneer Campus
PSP Element(s) G-510001-001
Grants Royal Academy of Engineering
Wellcome Trust
EPSRC
European Union - Next Generation EU
National Scientific Commission 5 for Technological and Inter-disciplinary Research
Italian National Institute for Nuclear Physics (INFN)
Royal Academy of Engineeringhttps://doi.org/10.13039/501100000287
DOI 10.1088/1361-6560/ad3328
WOS ID 001196678000001
Scopus ID 85189826097
PubMed ID 38471186
Erfassungsdatum 2024-05-08
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