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Fritz, V. ; Eisele, S.* ; Martirosian, P.* ; Machann, J. ; Schick, F.*

A straightforward procedure to build a non-toxic relaxometry phantom with desired T1 and T2 times at 3T.

Magn. Reson. Mater. Phys. Biol. Med., DOI: 10.1007/s10334-024-01166-7 (2024)
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OBJECTIVE: To prepare and analyze soy-lecithin-agar gels for non-toxic relaxometry phantoms with tissue-like relaxation times at 3T. METHODS: Phantoms mimicking the relaxation times of various tissues (gray and white matter, kidney cortex and medulla, spleen, muscle, liver) were built and tested with a clinical 3T whole-body MR scanner. Simple equations were derived to calculate the appropriate concentrations of soy lecithin and agar in aqueous solutions to achieve the desired relaxation times. Phantoms were tested for correspondence between measurements and calculated T1 and T2 values, reproducibility, spatial homogeneity, and temporal stability. T1 and T2 mapping techniques and a 3D T1-weighted sequence with high spatial resolution were applied. RESULTS: Except for the liver relaxation phantom, all phantoms were successfully and reproducibly produced. Good agreement was found between the targeted and measured relaxation times. The percentage deviations from the targeted relaxation times were less than 3% for T1 and less than 6.5% for T2. In addition, the phantoms were homogeneous and had little to no air bubbles. However, the phantoms were unstable over time: after a storage period of 4 weeks, mold growth and also changes in relaxation times were detected in almost all phantoms. CONCLUSION: Soy-lecithin-agar gels are a non-toxic material for the construction of relaxometry phantoms with tissue-like relaxation times. They are easy to prepare, inexpensive and allow independent adjustment of T1 and T2. However, there is still work to be done to improve the long-term stability of the phantoms.
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Publication type Article: Journal article
Document type Scientific Article
Keywords 3t ; Mri Phantom ; Relaxometry ; Soy Lecithin ; T1 ; T2; Doped Agarose-gel; T-2 Relaxation; Equivalent; Tissue
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 0968-5243
e-ISSN 1352-8661
Journal Magnetic Resonance Materials in Physics, Biology and Medicine
Publisher Springer
Publishing Place One New York Plaza, Suite 4600, New York, Ny, United States
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
POF-Topic(s) 90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502400-001
Grants
German Federal Ministry of Education and Research (BMBF)
German Research Foundation (DFG)
DOI 10.1007/s10334-024-01166-7
WOS ID 001220294500001
Scopus ID 85192797095
PubMed ID 38733487
Erfassungsdatum 2024-06-25
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