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Esih, H.* ; Mezgec, K.* ; Billmeier, M.* ; Malenšek, Š.* ; Benčina, M.* ; Grilc, B.* ; Vidmar, S.* ; Gašperlin, M.* ; Bele, M.* ; Zidarn, M.* ; Zupanc, T.L.* ; Morgan, T.* ; Jordan, I.* ; Sandig, V.* ; Schrödel, S.* ; Thirion, C.* ; Protzer, U. ; Wagner, R.* ; Lainšček, D.* ; Jerala, R.*

Mucoadhesive film for oral delivery of vaccines for protection of the respiratory tract.

J. Control. Release 371, 179-192 (2024)
DOI PMC
Creative Commons Lizenzvertrag
Open Access Green as soon as Postprint is submitted to ZB.
The delivery of vaccines plays a pivotal role in influencing the strength and longevity of the immune response and controlling reactogenicity. Mucosal immunization, as compared to parenteral vaccination, could offer greater protection against respiratory infections while being less invasive. While oral vaccination has been presumed less effective and believed to target mainly the gastrointestinal tract, trans-buccal delivery using mucoadhesive films (MAF) may allow targeted delivery to the mucosa. Here we present an effective strategy for mucosal delivery of several vaccine platforms incorporated in MAF, including DNA plasmids, viral vectors, and lipid nanoparticles incorporating mRNA (mRNA/LNP). The mRNA/LNP vaccine formulation targeting SARS-CoV-2 as a proof of concept remained stable within MAF consisting of slowly releasing water-soluble polymers and an impermeable backing layer, facilitating enhanced penetration into the oral mucosa. This formulation elicited antibody and cellular responses comparable to the intramuscular injection, but also induced the production of mucosal IgAs, highlighting its efficacy, particularly for use as a booster vaccine and the potential advantage for protection against respiratory infections. The MAF vaccine preparation demonstrates significant advantages, such as efficient delivery, stability, and simple noninvasive administration with the potential to alleviate vaccine hesitancy.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Mucoadhesive Film ; Mucosal Immunity ; Respiratory Infection ; Vaccine Delivery
ISSN (print) / ISBN 0168-3659
e-ISSN 1873-4995
Journal Journal of Controlled Release
Quellenangaben Volume: 371, Issue: , Pages: 179-192 Article Number: , Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)