PuSH - Publication Server of Helmholtz Zentrum München

Raeisi-Dehkordi, H.* ; Amiri, M.* ; Rathmann, W.* ; Zeller, T.* ; Adamski, J. ; Bano, A.* ; van der Schouw, Y.T.* ; Thorand, B. ; Muka, T.* ; Nano, J.

Sex hormone-binding globulin may explain sex differences for glucose homeostasis and incidence of type 2 diabetes: The KORA study.

Eur. J. Epidemiol., DOI: 10.1007/s10654-024-01136-2 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Research has indicated that sex hormone-binding globulin (SHBG) is associated with glucose homeostasis and may play a role in the etiology of type 2 diabetes (T2D). While it is unclear whether SHBG may mediate sex differences in glucose control and subsequently, incidence of T2D. We used observational data from the German population-based KORA F4 study (n = 1937, mean age: 54 years, 41% women) and its follow-up examination KORA FF4 (median follow-up 6.5 years, n = 1387). T2D was initially assessed by self-report and validated by contacting the physicians and/ or reviewing the medical charts. Mediation analyses were performed to assess the role of SHBG in mediating the association between sex (women vs. men) and glucose- and insulin-related traits (cross-sectional analysis) and incidence of T2D (longitudinal analysis). After adjustment for confounders, (model 1: adjusted for age; model 2: model 1 + smoking + alcohol consumption + physical activity), women had lower fasting glucose levels compared to men (β = -4.94 (mg/dl), 95% CI: -5.77, -4.11). SHBG levels were significantly higher in women than in men (β = 0.47 (nmol/l), 95% CI:0.42, 0.51). Serum SHBG may mediate the association between sex and fasting glucose levels with a proportion mediated (PM) of 30% (CI: 22-41%). Also, a potential mediatory role of SHBG was observed for sex differences in incidence of T2D (PM = 95% and 63% in models 1 and 2, respectively). Our novel findings suggest that SHBG may partially explain sex-differences in glucose control and T2D incidence.
Altmetric
Additional Metrics?
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Glycemic Control ; Mediation Analysis ; Sex Differences ; Sex Hormone-binding Globulin ; Type 2 Diabetes; Gender-differences; Mediation Analysis; Shbg Levels; Women; Risk; Associations; Obesity; Mellitus; Insulin; Impact
ISSN (print) / ISBN 0393-2990
e-ISSN 1573-7284
Publisher Springer
Publishing Place Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands
Non-patent literature Publications
Reviewing status Peer reviewed
Grants Swiss National Science Foundation under the "Spirit grant" (SNSF)
State of Bavaria
Helm-holtz Zentrum Munchen - German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)