PuSH - Publication Server of Helmholtz Zentrum München: Experimental colonization with <em>H. hepaticus, S. aureus </em>and <em>R. pneumotropicus </em>does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice.

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Wunderlich, M. ; Miller, M. ; Ritter, B. ; Le Gleut, R. ; Marchi, H. ; Majzoub-Altweck, M.* ; Knerr, P.J.* ; Douros, J.D.* ; Müller, T.D. ; Brielmeier, M.

Experimental colonization with H. hepaticus, S. aureus and R. pneumotropicus does not influence the metabolic response to high-fat diet or incretin-analogues in wildtype SOPF mice.

Mol. Metab. 87:101992 (2024)

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OBJECTIVE: We here assessed whether typical pathogens of laboratory mice affect the development of diet-induced obesity and glucose intolerance, and whether colonization affects the efficacy of the GLP-1R agonist liraglutide and of the GLP-1/GIP co-agonist MAR709 to treat obesity and diabetes. METHODS: Male C57BL/6J mice were experimentally infected with Helicobacter hepaticus, Rodentibacter pneumotropicus and Staphylococcus aureus and compared to a group of uninfected specific and opportunistic pathogen free (SOPF) mice. The development of diet-induced obesity and glucose intolerance was monitored over a period of 26 weeks. To study the influence of pathogens on drug treatment, mice were then subjected for 6 days daily treatment with either the GLP-1 receptor agonist liraglutide or the GLP-1/GIP co-agonist MAR709. RESULTS: Colonized mice did not differ from SOPF controls regarding HFD-induced body weight gain, food intake, body composition, glycemic control, or responsiveness to treatment with liraglutide or the GLP-1/GIP co-agonist MAR709. CONCLUSIONS: We conclude that the occurrence of Helicobacter hepaticus, Rodentibacter pneumotropicus and Staphylococcus aureus does neither affect the development of diet-induced obesity or type 2 diabetes, nor the efficacy of GLP-1-based drugs to decrease body weight and to improve glucose control in mice.

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