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Epigenomic differences between osteoarthritis grades in primary cartilage.
Osteoarthr. Cartil. 32, 1126-1133 (2024)
OBJECTIVE: Osteoarthritis is a common and complex joint disorder that shows higher prevalence and greater disease severity in women. Here, we investigate genome-wide methylation profiles of primary chondrocytes from osteoarthritis patients. DESIGN: We compare genome-wide methylation profiles of macroscopically intact (low-grade) and degraded (high-grade) osteoarthritis cartilage samples matched from osteoarthritis patients undergoing knee replacement surgery. We perform an epigenome-wide association study (EWAS) for cartilage degeneration across 170 patients and separately in 96 women and 74 men. RESULTS: We reveal widespread epigenetic differences with enrichments of nervous system and apoptosis-related processes. We further identify substantial similarities between sexes, but also sex-specific markers and pathways. CONCLUSIONS: Together, we provide the largest genome-wide methylation profiles of primary cartilage to date with enhanced and sex-specific insights into epigenetic processes underlying osteoarthritis progression.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Dna Methylation ; Ewas ; Osteoarthritis ; Cartilage ; Chondrocytes ; Sex Specificity; Sex-differences; Knee; Identification; Associations; Disability; Package; Pain
Language
english
Publication Year
2024
HGF-reported in Year
2024
ISSN (print) / ISBN
1063-4584
e-ISSN
1063-4584
Journal
Osteoarthritis and Cartilage
Quellenangaben
Volume: 32,
Issue: 9,
Pages: 1126-1133
Publisher
Elsevier
Publishing Place
125 London Wall, London, England
Reviewing status
Peer reviewed
Institute(s)
Institute of Translational Genomics (ITG)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Genetics and Epidemiology
PSP Element(s)
G-506700-001
WOS ID
001298018000001
Scopus ID
85200366656
PubMed ID
39053729
Erfassungsdatum
2024-07-29