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Coppens, A.* ; Verleden, S.E.* ; Claes, E.* ; Voet, H.* ; Verleden, G.M.* ; Lapperre, T.S.* ; Yildirim, A.Ö. ; Jungraithmayr, W.* ; Yamada, Y.* ; Peeters, D.J.* ; Hendriks, J.M.H.*

Murine orthotopic lung transplant models: A comprehensive overview of genetic mismatch degrees and histopathological insights into chronic lung allograft dysfunction.

Am. J. Transplant., DOI: 10.1016/j.ajt.2024.07.033 (2024)
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Currently, lung transplantation outcome remains inferior compared to other solid organ transplantations. A major cause for limited survival after lung transplantation is chronic lung allograft dysfunction (CLAD). Numerous animal models have been developed to investigate CLAD in order to discover adequate treatments. The murine orthotopic lung transplant model has been further optimized over the last years. However, different degrees of genetic mismatch between donor and recipient mice have been used, applying a single, minor, moderate and major genetic mismatch. This review aims to reassess the existing murine mismatch models and to provide a comprehensive overview, with a specific focus on their eventual histopathologic presentation. This will be crucial to leverage this model and to tailor it according to specific research needs.
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Publication type Article: Journal article
Document type Review
Keywords Chronic Lung Allograft Dysfunction ; Lung Transplantation ; Mouse Model
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 1600-6135
e-ISSN 1600-6143
Journal American Journal of Transplantation
Publisher Wiley
Publishing Place Hoboken, NJ
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-505000-007
DOI 10.1016/j.ajt.2024.07.033
Scopus ID 85201495383
PubMed ID 39098448
Erfassungsdatum 2024-09-17
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