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Yuan, X.Q.* ; Zhou, N.* ; Song, S.J.* ; Xie, Y.X.* ; Chen, S.Q.* ; Yang, T.F.* ; Peng, X.* ; Zhang, C.-Y. ; Zhu, Y.H.* ; Peng, L.*

Decoding the genomic enigma: Approaches to studying extrachromosomal circular DNA.

Heliyon 10:e36659 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Extrachromosomal circular DNA (eccDNA), a pervasive yet enigmatic component of the eukaryotic genome, exists autonomously from its chromosomal counterparts. Ubiquitous in eukaryotes, eccDNA plays a critical role in the orchestration of cellular processes and the etiology of diseases, particularly cancers. However, the full scope of its influence on health and disease remains elusive, presenting a rich vein of research yet to be mined. Unraveling the complexities of eccDNA necessitates a distillation of methodologies — from biogenesis to functional analysis — a landscape we overview in this study with precision and clarity. Here, we systematically outline cutting-edge methodologies from high-throughput sequencing and bioinformatics to experimental validations, showcasing the intricate world of eccDNAs. We combed through a treasure trove of auxiliary research resources and analytical tools. Moreover, we chart a course for future inquiry, illuminating the horizon with potential groundbreaking strategies for designing eccDNA research projects and pioneering new methodological frontiers.
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Publication type Article: Journal article
Document type Review
Keywords Analytical Tool ; Approach ; Eccdna ; Ecdna ; Experimental Method ; Extrachromosomal Circular Dna ; High-throughput Sequencing ; Methodology ; Single Cell; Evolution; Shape
Language english
Publication Year 2024
HGF-reported in Year 2024
ISSN (print) / ISBN 2405-8440
e-ISSN 2405-8440
Journal Heliyon
Quellenangaben Volume: 10, Issue: 17, Pages: , Article Number: e36659 Supplement: ,
Publisher Elsevier
Publishing Place London [u.a.]
Reviewing status Peer reviewed
Institute(s) Research Unit Analytical Pathology (AAP)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-500390-001
Grants
Guangzhou Basic and Applied Basic Research Foundation
Science and Technology Planning Project of Guangdong Province
Fundamental Research Funds for the Central Universities
(Guangdong-Dongguan Joint Fund)
DOI 10.1016/j.heliyon.2024.e36659
WOS ID 001301914900001
Scopus ID 85201772851
PubMed ID 39263178
Erfassungsdatum 2024-09-10
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