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Takenaka, S. ; Möller, W. ; Semmler-Behnke, M. ; Karg, E.W. ; Wenk, A. ; Schmid, O. ; Stöger, T. ; Jennen, L. ; Aichler, M. ; Walch, A.K. ; Pokhrel, S.* ; Mädler, L.* ; Eickelberg, O. ; Kreyling, W.G.

Efficient internalization and intracellular translocation of inhaled gold nanoparticles in rat alveolar macrophages.

Nanomed. 7, 855-865 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Aim: To investigate the relationship of alveolar macrophages and inhaled nanoparticles in the lung. Materials & methods: Rats were exposed by inhalation to 14 nm gold nanoparticles for 6 hours, and ultramicroscopic observation on the frequency and localization of gold nanoparticles within lavaged macrophages was performed up to 7 days. Results & discussion: The majority of macrophages examined on day 0 (94%) contained internalized gold nanoparticles, and the percentage decreased to 59% on day 7. Gold nanoparticles were exclusively found within cytoplasmic vesicles. On day 0, most gold nanoparticles appeared to be individual or slightly agglomerated, and they were frequently agglomerated on day 7. Conclusion: Alveolar macrophages efficiently internalized nanoparticles by endocytosis, and re-arrangements of vesicles and of nanoparticles in the vesicles of macrophages occurred.
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Publication type Article: Journal article
Document type Scientific Article
Keywords nanoparticle, inhalation, gold, alveolar macrophage, internalization; cellular trafficking
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 1743-5889
e-ISSN 1748-6963
Journal Nanomedicine
Quellenangaben Volume: 7, Issue: 6, Pages: 855-865 Article Number: , Supplement: ,
Publisher Future Medicine
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
Research Unit Analytical Pathology (AAP)
Institute of Pathology (PATH)
Cooperation Group Comprehensive Molecular Analytics (CMA)
POF-Topic(s) 30503 - Chronic Diseases of the Lung and Allergies

30202 - Environmental Health
30205 - Bioengineering and Digital Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Lung Research

Enabling and Novel Technologies
PSP Element(s) G-505000-009
G-505000-002
G-501600-001
G-505000-008
G-505000-001
G-500390-001
G-500300-001
PubMed ID 22475647
DOI 10.2217/NNM.11.152
WOS ID WOS:000305713400014
Scopus ID 84862870150
Erfassungsdatum 2012-04-04
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