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Müller, A. ; Klena, N.* ; Pang, S.* ; Galicia Garcia, L.E. ; Topcheva, O. ; Aurrecoechea Duran, S. ; Sulaymankhil, D. ; Seliskar, M. ; Mziaut, H. ; Schöniger, E. ; Friedland, D. ; Kipke, N. ; Kretschmar, S.* ; Münster, C. ; Weitz, J.* ; Distler, M.* ; Kurth, T.* ; Schmidt, D.* ; Hess, H.F.* ; Xu, C.S.* ; Pigino, G.* ; Solimena, M.

Structure, interaction and nervous connectivity of beta cell primary cilia.

Nat. Commun. 15:9168 (2024)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Primary cilia are sensory organelles present in many cell types, partaking in various signaling processes. Primary cilia of pancreatic beta cells play pivotal roles in paracrine signaling and their dysfunction is linked to diabetes. Yet, the structural basis for their functions is unclear. We present three-dimensional reconstructions of beta cell primary cilia by electron and expansion microscopy. These cilia are spatially confined within deep ciliary pockets or narrow spaces between cells, lack motility components and display an unstructured axoneme organization. Furthermore, we observe a plethora of beta cell cilia-cilia and cilia-cell interactions with other islet and non-islet cells. Most remarkably, we have identified and characterized axo-ciliary synapses between beta cell cilia and the cholinergic islet innervation. These findings highlight the beta cell cilia's role in islet connectivity, pointing at their function in integrating islet intrinsic and extrinsic signals and contribute to understanding their significance in health and diabetes.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 15, Issue: 1, Pages: , Article Number: 9168 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Pancreatic Beta Cell Research (IPI)