Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
DOI
 |
Free by publisher |
as soon as is submitted to ZB.
Non-negative universal differential equations with applications in systems biology.
In: (10th IFAC Conference on Foundations of Systems Biology in Engineering, FOSBE 2024, 8-11 September 2024, Corfu Island). Frankfurt ; München [u.a.]: Elsevier, 2024. 25-30 (IFAC PapersOnline ; 58)
Universal differential equations (UDEs) leverage the respective advantages of mechanistic models and artificial neural networks and combine them into one dynamic model. However, these hybrid models can suffer from unrealistic solutions, such as negative values for biochemical quantities. We present non-negative UDE (nUDEs), a constrained UDE variant that guarantees non-negative values. Furthermore, we explore regularisation techniques to improve generalisation and interpretability of UDEs.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Conference contribution
Keywords
Kinetic Modelling And Control Of Biological Systems ; Neural Networks ; Parameter And State Estimation ; Parametric Optimization ; Systems Biology
ISSN (print) / ISBN
2405-8963
e-ISSN
1474-6670
Conference Title
10th IFAC Conference on Foundations of Systems Biology in Engineering, FOSBE 2024
Conference Date
8-11 September 2024
Conference Location
Corfu Island
Journal
IFAC-PapersOnLine
Quellenangaben
Volume: 58,
Issue: 23,
Pages: 25-30
Publisher
Elsevier
Publishing Place
Frankfurt ; München [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)