PuSH - Publication Server of Helmholtz Zentrum München: Non-negative universal differential equations with applications in systems biology.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

EVA: Electronic Publishing

New EVA Application

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Philipps, M.* ; Körner, A.* ; Vanhoefer, J.* ; Pathirana, D.* ; Hasenauer, J.

Non-negative universal differential equations with applications in systems biology.

In: (10th IFAC Conference on Foundations of Systems Biology in Engineering, FOSBE 2024, 8-11 September 2024, Corfu Island). Frankfurt ; München [u.a.]: Elsevier, 2024. 25-30 (IFAC PapersOnline ; 58)

Publ. Version/Full Text

DOI

	Free by publisher

Abstract
Metrics
Extra information

Universal differential equations (UDEs) leverage the respective advantages of mechanistic models and artificial neural networks and combine them into one dynamic model. However, these hybrid models can suffer from unrealistic solutions, such as negative values for biochemical quantities. We present non-negative UDE (nUDEs), a constrained UDE variant that guarantees non-negative values. Furthermore, we explore regularisation techniques to improve generalisation and interpretability of UDEs.

Altmetric