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Insights into the molecular underpinning of type 2 diabetes complications.
Hum. Mol. Genet. 34, 469-480 (2025)
Type 2 diabetes (T2D) complications pose a significant global health challenge. Omics technologies have been employed to investigate these complications and identify the biological pathways involved. In this review, we focus on four major T2D complications: diabetic kidney disease, diabetic retinopathy, diabetic neuropathy, and cardiovascular complications. We discuss advancements in omics research, summarizing findings from genetic, epigenomic, transcriptomic, proteomic, and metabolomic studies across different ancestries and disease-relevant tissues. We stress the importance of integrating multi-omics techniques to elucidate the biological mechanisms underlying T2D complications and advocate for ancestrally diverse studies. Ultimately, these insights will improve risk prediction for T2D complications and inform translation strategies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Type 2 Diabetes Complications ; Epigenomics ; Metabolomics ; Proteomics ; Transcriptomics; Genome-wide Association; Coronary-heart-disease; Glomerular-filtration-rate; All-cause Mortality; Renal-disease; Cardiovascular-disease; Oxidative Stress; Glycemic Control; Acid-metabolism; Genetic Variant
ISSN (print) / ISBN
0964-6906
e-ISSN
1460-2083
Journal
Human Molecular Genetics
Quellenangaben
Volume: 34,
Issue: 6,
Pages: 469-480
Publisher
Oxford University Press
Publishing Place
Great Clarendon St, Oxford Ox2 6dp, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Translational Genomics (ITG)
Grants
European Union