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Dean, J.* ; Hoch, C.C.* ; Wollenberg, B.* ; Navidzadeh, J.* ; Maheta, B.* ; Mandava, A.* ; Knoedler, S. ; Sherwani, K. ; Baecher, H. ; Schmitz, A.* ; Alfertshofer, M.* ; Heiland, M.* ; Kreutzer, K.* ; Koerdt, S.* ; Knoedler, L.*

Advancements in bioengineered and autologous skin grafting techniques for skin reconstruction: A comprehensive review.

Front. Bioeng. Biotechnol. 12:1461328 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The reconstruction of complex skin defects challenges clinical practice, with autologous skin grafts (ASGs) as the traditional choice due to their high graft take rate and patient compatibility. However, ASGs have limitations such as donor site morbidity, limited tissue availability, and the necessity for multiple surgeries in severe cases. Bioengineered skin grafts (BSGs) aim to address these drawbacks through advanced tissue engineering and biomaterial science. This study conducts a systematic review to describe the benefits and shortcomings of BSGs and ASGs across wound healing efficacy, tissue integration, immunogenicity, and functional outcomes focusing on wound re-epithelialization, graft survival, and overall aesthetic outcomes. Preliminary findings suggest ASGs show superior early results, while BSGs demonstrate comparable long-term outcomes with reduced donor site morbidity. This comparative analysis enhances understanding of bioengineered alternatives in skin reconstruction, potentially redefining best practices based on efficacy, safety, and patient-centric outcomes, highlighting the need for further innovation in bioengineered solutions.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Autologous Skin Grafting ; Bioengineered Skin Grafts ; Dermatologic Surgery ; Human Skin Substitute ; Plastic Surgery ; Skin Deficits; Tissue-engineered Skin; Hyaluronic-acid; Wound Repair; Stem-cells; Vascularization Strategies; Chemokine Receptors; Nerve Regeneration; Cultured-cells; Clinical-trial; Growth-factor
ISSN (print) / ISBN 2296-4185
e-ISSN 2296-4185
Journal Frontiers in bioengineering and biotechnology
Quellenangaben Volume: 12, Issue: , Pages: , Article Number: 1461328 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)