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Ramundi, V. ; Zdouc, M.M.* ; Donati, E.* ; van der Hooft, J.J.J.* ; Cimini, S.* ; Righetti, L.*

Non-targeted metabolomics-based molecular networking enables the chemical characterization of Rumex sanguineus, a wild edible plant.

Metabolomics 21:19 (2025)

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INTRODUCTION AND OBJECTIVE: Rumex sanguineus, a traditional medicinal plant of the Polygonaceae family, is gaining popularity as an edible resource. However, despite its historical and nutritional significance, its chemical composition remains poorly understood. To deepen the understanding of the of Rumex sanguineus composition, an in-depth analysis using non-targeted, mass spectrometry-based metabolomics was performed. METHODS: Rumex roots, stems and leaves samples were analyzed by UHPLC-HRMS and subsequently subjected to feature-based molecular networking. RESULTS AND CONCLUSION: Overall, 347 primary and specialized metabolites grouped into 8 biochemical classes were annotated. Most of these metabolites (60%) belong to the polyphenols and anthraquinones classes. To investigate potential' toxicity due to the presence of anthraquinones, the amount of emodin was quantified with analytical standard, revealing higher accumulation in leaves compared to stems and roots. This highlights the need for thorough metabolomic studies to understand both beneficial and harmful compounds, especially in plants with historical medicinal use transitioning to modern culinary use.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Emodin ; Feature-based Molecular Networking ; Metabolomics ; Polyphenols ; Specialized Metabolites ; Wild Edible Plants; Mass-spectrometry; Electrospray-ionization; Anthocyanins; Emodin; Fragmentation; Products; L.

ISSN (print) / ISBN 1573-3882

e-ISSN 1573-3890

Journal Metabolomics

Quellenangaben Volume: 21, Issue: 1, Article Number: 19

Publisher Springer

Publishing Place New York, NY

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) CF Metabolomics & Proteomics (CF-MPC)

Grants European Union - NextGenerationEU
Wageningen Graduate School
European Union
University and Research