Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
Research data
DOI
PMC
 |
Open Access Gold |
|
as soon as is submitted to ZB.
Metabolic heterogeneity in tumor cells impacts immunology in lung squamous cell carcinoma.
OncoImmunology 14:2457797 (2025)
Metabolic processes are crucial in immune regulation, yet the impact of metabolic heterogeneity on immunological functions remains unclear. Integrating metabolomics into immunology allows the exploration of the interactions of multilayered features in the biological system and the molecular regulatory mechanism of these features. To elucidate such insight in lung squamous cell carcinoma (LUSC), we analyzed 106 LUSC tumor tissues. We performed high-resolution matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) to obtain spatial metabolic profiles, and immunohistochemistry to detect tumor-infiltrating T lymphocytes (TILs). Unsupervised k-means clustering and Simpson's diversity index were employed to assess metabolic heterogeneity, identifying five distinct metabolic tumor subpopulations. Our findings revealed that TILs are specifically associated with metabolite distributions, not randomly distributed. Integrating a validation cohort, we found that heterogeneity-correlated metabolites interact with CD8+ TIL-associated genes, affecting survival. High metabolic heterogeneity was linked to worse survival and lower TIL levels. Pathway enrichment analyses highlighted distinct metabolic pathways in each subpopulation and their potential responses to chemotherapy. This study uncovers the significant impact of metabolic heterogeneity on immune functions in LUSC, providing a foundation for tailoring therapeutic strategies.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Immunology ; Spatial Metabolomics ; Lung Cancer ; Metabolic Heterogeneity ; Metabolic Tumor Subpopulation; Infiltrating T-cells; Cancer; Resistance; Microenvironment; Head; Immunometabolism; Mechanisms
ISSN (print) / ISBN
2162-4011
e-ISSN
2162-402X
Journal
OncoImmunology
Quellenangaben
Volume: 14,
Issue: 1,
Article Number: 2457797
Publisher
Taylor & Francis
Publishing Place
Philadelphia
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Research Unit Analytical Pathology (AAP)
Grants
Cancer Research Switzerland
Stiftung zur Krebsbekaempfung
Deutsche Krebshilfe
China Scholarship Council
Ministry of Education and Research of the Federal Republic of Germany
Deutsche Forschungsgemeinschaft
Stiftung zur Krebsbekaempfung
Deutsche Krebshilfe
China Scholarship Council
Ministry of Education and Research of the Federal Republic of Germany
Deutsche Forschungsgemeinschaft