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Open Access Green as soon as Postprint is submitted to ZB.
Regulation of peripheral glucose levels during human sleep.
Sleep:zsaf042 (2025)
Studies in rats indicate that oscillatory signatures of memory processing during sleep, and specifically hippocampal sharp wave-ripples, also regulate peripheral glucose concentration. Here, we examined whether there is a similar link between such signatures of memory processing and glucose regulation during sleep in healthy humans. We obtained polysomnographic recordings and continuous recordings of peripheral interstitial glucose levels (1 sample/min) from 10 participants (5 females) during two consecutive nights. Temporal relationships between EEG events of interest and glucose levels were examined using cross-correlation functions and time-event histograms. Confirming the findings in rats, we find that sleep spindles, a core signature of sleep-dependent memory processing, are followed within 1-6 min by a robust decrease in glucose concentrations. By contrast, slow oscillation events hallmarking slow wave sleep (SWS) were followed, with a lag of 5-11 min, by an increase in glucose levels. Transitions into rapid eye movement (REM) sleep were followed by a glucose decrease after 10-14 min, whereas awakenings and microarousals were linked to immediate glucose increases. These temporal relationships indicate a sleep-specific regulation of peripheral glucose concentrations that is linked to both signatures of sleep-dependent memory processing as well as the macro-architecture of sleep. They possibly reflect noradrenergic regulation of sympathetic activity via the brainstem locus coeruleus, and may be of relevance in clinical conditions with concurrent disturbances of sleep and glucose regulation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Diabetes ; Neuroendocrinology ; Sleep Spindle ; Slow Waves
ISSN (print) / ISBN
0161-8105
e-ISSN
1550-9109
Journal
Sleep
Quellenangaben
Article Number: zsaf042
Publisher
American Academy of Sleep Medicine and the Sleep Research Society
Non-patent literature
Publications
Reviewing status
Peer reviewed