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The metabolic signature of cardiorespiratory fitness.
Scand. J. Med. Sci. Sports 35:e70034 (2025)
Publ. Version/Full Text
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DOI
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High cardiorespiratory fitness (CRF) is associated with better overall health. This study aimed to find a metabolic signature associated with CRF to identify health-promoting effects. CRF based on cardiopulmonary exercise testing, targeted and untargeted metabolomics approaches based on mass spectrometry, and clinical data from two independent cohorts of the Study of Health in Pomerania (SHIP) were used. Sex-stratified linear regression models were adjusted for age, smoking, and height to relate CRF with individual metabolites. A total of 132 (SHIP-START-2: 483 men with a median age of 58 years and 450 women with a median age of 56 years) and 118 (SHIP-TREND-0: 341 men and 371 women both with a median age of 51 years) metabolites were associated with CRF. Lipids showed bidirectional relations to CRF independent of sex. Specific subsets of sphingomyelins were positively related to CRF in men (SM (OH) C14:1, SM(OH)C22:2 SM C16:0, SM C20:2 SM(OH)C24:1) and inversely in women (SM C16:1, SM C18:0, SM C18:1). Metabolites involved in energy production (citrate and succinylcarnitine) were only associated with CRF in men. In women, xenobiotics (hippurate, stachydrine) were related to CRF. The sex-specific metabolic signature of CRF is influenced by sphingomyelins, energy substrates, and xenobiotics. The greater effect estimates seen in women may emphasize the important role of CRF in maintaining metabolic health. Future research should explore how this profile changes with different types of exercise interventions or diseases in diverse populations and how these metabolites could be implemented in primary prevention settings.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cardiorespiratory Fitness ; Epidemiology ; Exercise Testing ; Metabolomics; Acid Oxidation Contribute; Plasma Acylcarnitines; Insulin-resistance; Profiles; Obesity; Risk; Age; Association; Sex
ISSN (print) / ISBN
0905-7188
e-ISSN
1600-0838
Quellenangaben
Volume: 35,
Issue: 3,
Article Number: e70034
Publisher
Wiley
Publishing Place
Oxford
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Bioinformatics and Systems Biology (IBIS)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Experimental Genetics (IEG)
CF Metabolomics & Proteomics (CF-MPC)
Institute of Experimental Genetics (IEG)
Grants
Projekt DEAL
German Federal State of Mecklenburg-West Pomerania
German Federal State of Mecklenburg-West Pomerania