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Baum, P.* ; Ebert, T.* ; Klöting, N. ; Krupka, S. ; König, M.* ; Paeschke, S.* ; Stock, P.* ; Bulc, M.* ; Blüher, M. ; Palus, K.* ; Nowicki, M.* ; Kosacka, J.*

Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus.

Neurosci. Res., DOI: 10.1016/j.neures.2025.04.002 (2025)
Article in press DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient ob/ob mice, leptin receptor-deficient db/db) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (RT1u) WOKW rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Pdn ; T2d ; Wokw Rat ; Autophagy ; Db/db Mice ; Inflammation ; Metabolic Syndrome ; Ob/ob Mice
ISSN (print) / ISBN 0168-0102
e-ISSN 0168-0102
Journal Neuroscience Research
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)