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Baum, P.* ; Ebert, T.* ; Klöting, N. ; Krupka, S. ; König, M.* ; Paeschke, S.* ; Stock, P.* ; Bulc, M.* ; Blüher, M. ; Palus, K.* ; Nowicki, M.* ; Kosacka, J.*

Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus.

Neurosci. Res. 216:104899 (2025)
Publ. Version/Full Text DOI PMC
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Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient ob/ob mice, leptin receptor-deficient db/db) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (RT1u) WOKW rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Pdn ; T2d ; Wokw Rat ; Autophagy ; Db/db Mice ; Inflammation ; Metabolic Syndrome ; Ob/ob Mice; Neuropathic Pain; M2 Macrophages; Obesity; Rats
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 0168-0102
e-ISSN 0168-0102
Journal Neuroscience Research
Quellenangaben Volume: 216, Issue: , Pages: , Article Number: 104899 Supplement: ,
Publisher Elsevier
Publishing Place Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-506500-001
G-506501-001
Grants German Research Foundation-project
DOI 10.1016/j.neures.2025.04.002
WOS ID 001516332300004
Scopus ID 105003690932
PubMed ID 40252698
Erfassungsdatum 2025-05-10
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