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Inflammation and autophagy in peripheral nerves of rodent models with metabolic syndrome and type 2 diabetes mellitus.
Neurosci. Res. 216:104899 (2025)
Metabolic syndrome (MetS) and type 2 diabetes mellitus (T2D) are associated with inflammation and the accumulation of macrophages in peripheral nerves, which increases the risk of developing peripheral neuropathy (PN). We have previously investigated that macrophage infiltration in the peripheral nerves of animals with T2D (leptin-deficient ob/ob mice, leptin receptor-deficient db/db) correlated with PN, whereas this process in animals with MetS (Wistar Ottawa Karlsburg W (RT1u) WOKW rat) did not lead to neuropathic changes. Additional data presented in this study suggest an association between increased mRNA expression of the anti-inflammatory marker IL-10 and autophagy in the prevention of neuropathy.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Pdn ; T2d ; Wokw Rat ; Autophagy ; Db/db Mice ; Inflammation ; Metabolic Syndrome ; Ob/ob Mice; Neuropathic Pain; M2 Macrophages; Obesity; Rats
ISSN (print) / ISBN
0168-0102
e-ISSN
0168-0102
Journal
Neuroscience Research
Quellenangaben
Volume: 216,
Article Number: 104899
Publisher
Elsevier
Publishing Place
Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
German Research Foundation-project