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Valencia-Hernández, C.A.* ; Yu, Z.* ; Gehring, U.* ; Koppelman, G.H.* ; Standl, M. ; Flexeder, C. ; Schikowski, T.* ; Kress, S.* ; Melén, E.* ; Gruzieva, O.* ; Lõhmus, M.* ; Faner, R.* ; Agusti, A.* ; Wedzicha, J.A.* ; Garcia-Aymerich, J.* ; Koch, S.* ; Nieuwenhuijsen, M.* ; Lertxundi, A.* ; Esplugues, A.* ; Ballester, F.* ; Arregi, A.* ; Markevych, I.* ; Bloom, C.I.* ; Fuertes, E.*

Residential greenspace and lung function throughout childhood and adolescence in five European birth cohorts. A CADSET initiative.

Environ. Int. 199:109493 (2025)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Whether greenspace affects lung function is unclear. We explored associations between the level of greenness or presence of urban green space near the home with lung function measures taken repeatedly during childhood and adolescence in five European birth cohorts. Lung function was measured by spirometry between six and 22 years (2-3 times), and 9,206 participants from BAMSE (Sweden), GINI/LISA South and GINI/LISA North (Germany), PIAMA (The Netherlands) and INMA (Spain) contributed at least one lung function measurement. The mean Normalized Difference Vegetation Index (NDVI) in a 300 m buffer and presence of urban green space within a 300 m buffer (yes/no) were estimated at the home address at the time of each spirometry measurement. Cohort-specific associations were assessed using adjusted linear mixed models and combined in a random-effects meta-analysis. Residential greenness was not associated with forced expiratory volume in one second (FEV1), forced vital capacity (FVC) or FEV1/FVC in the meta-analysis (2.3 ml [-3.2, 7.9], 6.2 ml [-3.4, 15.7] and -0.1 [-0.3, 0.1] per 0.1 increase in NDVI, respectively), nor was having a nearby urban green space (-8.6 ml [-22.3, 5.0], -7.6 ml [-24.7, 9.4] and 0.0 [-0.4, 0.3], respectively). Heterogeneity was low to moderate (I2 = 0 -39 %). Asthma, atopy, air pollution, sex, socioeconomic status and urbanization did not modify the null associations. Using repeated data from five large independent European birth cohorts, we did not find associations between vegetation levels around the home or the presence of an urban green space and lung function levels during childhood and adolescence.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Adolescence ; Children ; Cohort ; Greenness ; Greenspace ; Lung Function; Air-pollution Exposure; Y Medio Ambiente-(environment; Use Regression-models; Pm2.5 Absorbency; Health; Areas; No2; Intervention; Metaanalysis; Giniplus
ISSN (print) / ISBN 0160-4120
e-ISSN 1873-6750
Journal Environment International
Quellenangaben Volume: 199, Issue: , Pages: , Article Number: 109493 Supplement: ,
Publisher Elsevier
Publishing Place The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Grants European Research Council (ERC)
Fundacio Roger Torne
Fundacio La Caixa
Generalitat de Catalunya
Ministerio de Educacion y Ciencia
European Union
Fondo de Investigacion Sanitaria
CIBER Epidemiologia y Salud Pblica (CIBERESP)
Instituto de Salud Carlos III, Red de Centros de investigacion en Epidemiologia y Salud Pblica (RCESP)
Commission of the European Communities
Federal Ministry for Environment
Research Institute at Marien-Hospital Wesel
Consejeria de Salud de Andalucia
Junta the Andalucia
Conselleria de Sanitat de la Generalitat Valenciana
National Science Centre, Poland
European Research Council (ERC) under the European Union
Imperial College Research Fellowship
Generalitat de Catalunya through the CERCA Program
Azkoitia in Gipuzkoa
KUTXA-Caja Gipuzkoa San Sebastia
Diputacion Floral de Gipuzkoa
Departamento de Sanidad-Gobierno Vasco
Spanish Association against the Cancer (AECC) (Delegacion Provincial Asturias)
CAJASTUR-Caja Asturias
Honnef