OpenSSL SSL_connect: Connection reset by peer in connection to v2.sherpa.ac.uk:443 PuSH - Publication Server of Helmholtz Zentrum München: Exercise protects against high-fat diet-induced hypothalamic inflammation.

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Yi, C.-X. ; Al-Massadi, O.* ; Donelan, E.* ; Lehti, M.* ; Weber, J.* ; Ress, C.* ; Trivedi, C.* ; Müller, T.D. ; Woods, S.C.* ; Hofmann, S.M.

Exercise protects against high-fat diet-induced hypothalamic inflammation.

Physiol. Behav. 106, 485-490 (2012)
Publ. Version/Full Text Volltext DOI PMC
Creative Commons Lizenzvertrag
Open Access Green as soon as Postprint is submitted to ZB.
Hypothalamic inflammation is a potentially important process in the pathogenesis of high-fat diet-induced metabolic disorders that has recently received significant attention. Microglia are macrophage-like cells of the central nervous system which are activated by pro-inflammatory signals causing local production of specific interleukins and cytokines, and these in turn may further promote systemic metabolic disease. Whether or how this microglial activation can be averted or reversed is unknown. Since running exercise improves systemic metabolic health and has been found to promote neuronal survival as well as the recovery of brain functions after injury, we hypothesized that regular treadmill running may blunt the effect of western diet on hypothalamic inflammation. Using low-density lipoprotein receptor deficient (ldlr-/-) mice to better reflect human lipid metabolism, we first confirmed that microglial activation in the hypothalamus is severely increased upon exposure to a high-fat, or "western", diet. Moderate, but regular, treadmill running exercise markedly decreased hypothalamic inflammation in these mice. Furthermore, the observed decline in microglial activation was associated with an improvement of glucose tolerance. Our findings support the hypothesis that hypothalamic inflammation can be reversed by exercise and suggest that interventions to avert or reverse neuronal damage may offer relevant potential in obesity treatment and prevention.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Treadmill; Exercise; Hypothalamus; Inflammation; Obesity; ENDOPLASMIC-RETICULUM STRESS; INSULIN-RESISTANCE; GLUCOSE-TOLERANCE; LEPTIN RESISTANCE; KAPPA-B; ACTIVATION; VOLUNTARY; MICE; MICROGLIA; OBESITY
ISSN (print) / ISBN 0031-9384
e-ISSN 1873-507X
Journal Physiology & Behavior
Quellenangaben Volume: 106, Issue: 4, Pages: 485-490 Article Number: , Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Diabetes and Obesity (IDO)