Abel, L.* ; Richer, R.* ; Burkhardt, F.* ; Kurz, M.* ; Ringgold, V.* ; Schindler-Gmelch, L.* ; Eskofier, B.M. ; Rohleder, N.*
     
    
        
Body movements as biomarkers: Machine Learning-based prediction of HPA axis reactivity to stress.
    
    
        
    
    
        
        Psychoneuroendocrinology 179:107528 (2025)
    
    
    
      
      
	
	    Body movements and posture provide valuable insights into stress responses, yet their relationship with endocrine biomarkers of the stress response remains underexplored. This study investigates whether movement patterns during the Trier Social Stress Test (TSST) and the friendly-TSST (f-TSST) can predict cortisol reactivity. Using motion capturing, movement data from 41 participants were analyzed alongside salivary cortisol responses. Machine learning models achieved a classification accuracy of 65.2 % for distinguishing cortisol responders from non-responders and a regression mean absolute error of 2.94 nmol/l for predicting cortisol increase. Findings suggest that movement dynamics can serve as proxies of endocrine stress responses, contributing to objective, non-invasive stress assessment methods.
	
	
	    
	
       
      
	
	    
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        Publication type
        Article: Journal article
    
 
    
        Document type
        Scientific Article
    
 
    
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        Keywords
        Cortisol ; Machine Learning ; Movement ; Posture ; Stress ; Tsst; Psychosocial Stress; Salivary Cortisol; Responses; Law; Perception; Expression; Shame; Life
    
 
    
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        Language
        english
    
 
    
        Publication Year
        2025
    
 
    
        Prepublished in Year
        0
    
 
    
        HGF-reported in Year
        2025
    
 
    
    
        ISSN (print) / ISBN
        0306-4530
    
 
    
        e-ISSN
        1873-3360
    
 
    
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	    Volume: 179,  
	    Issue: ,  
	    Pages: ,  
	    Article Number: 107528 
	    Supplement: ,  
	
    
 
    
        
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            Elsevier
        
 
        
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            The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, England
        
 
	
        
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        Reviewing status
        Peer reviewed
    
 
    
        Institute(s)
        Institute of AI for Health (AIH)
    
 
    
        POF-Topic(s)
        30205 - Bioengineering and Digital Health
    
 
    
        Research field(s)
        Enabling and Novel Technologies
    
 
    
        PSP Element(s)
        G-540008-001
    
 
    
        Grants
        Deutsche Forschungsgemeinschaft (DFG, German Research foundation)
    
 
    
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        Erfassungsdatum
        2025-07-03