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Xu, P. ; Fundneider, S. ; Lange, B. ; Maksym, R.P. ; Stuttmann, J.* ; Schäffner, A.

A root-based N-hydroxypipecolic acid standby circuit to direct immunity and growth of Arabidopsis shoots.

Nat. Plants, DOI: 10.1038/s41477-025-02053-2 (2025)
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Soil-borne microorganisms can systemically affect shoot resistance to pathogens relying on jasmonic acid and/or salicylic acid. However, the emanating root triggers in these scenarios remain elusive. Here we identify an N-hydroxypipecolic-acid-(NHP-)directed, salicylic-acid-related mechanism of root-triggered systemic resistance in Arabidopsis, which uses components of systemic acquired resistance known in leaves. However, in contrast to the inductive nature of systemic acquired resistance, FLAVIN-DEPENDENT MONOOXYGENASE 1 (FMO1) continuously synthesizes NHP in roots, while the glucosyltransferase UGT76B1 concomitantly conjugates and immobilizes NHP. Physical grafting experiments and tissue-specific knockouts revealed that the loss of UGT76B1 in roots leads to enhanced NHP release, initiating shoot responses. This counteracting standby FMO1/UGT76B1 circuit is specifically and sensitively modulated by root-associated microorganisms. Endophytic and (hemi)biotrophic fungi induce UGT76B1 degradation and FMO1 expression, resulting in varying levels of NHP being released to the shoot, where this root signal differently modulates defence and growth.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Systemic Acquired-resistance; Hydroxy-pipecolic Acid; Fusarium-oxysporum; Plant Defense; Ugt76b1; Monooxygenase; Gene; Colonization; Induction; Thaliana
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2055-026X
e-ISSN 2055-0278
Journal Nature Plants
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Research Unit Environmental Simulation (EUS)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Environmental Sciences
PSP Element(s) G-504900-007
Grants Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH)
DOI 10.1038/s41477-025-02053-2
WOS ID 001532501200001
Scopus ID 105011258144
PubMed ID 40696005
Erfassungsdatum 2025-07-25
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