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Keim, P.M.* ; Greimel, E.* ; Feldmann, L.* ; Piechaczek, C.E.* ; Harris, C. ; Flexeder, C. ; Berdel, D.* ; von Berg, A.* ; Koletzko, S.* ; Bauer, C.P.* ; Schikowski, T.* ; Herberth, G.* ; Heinrich, J. ; Schulte-Körne, G.* ; Standl, M.

Prospective association between psychopathological symptoms in childhood and asthma in adolescence: Results from the GINIplus and LISA birth cohort studies.

Pediatr. Allergy Immunol. 36, 13:e70151 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
BACKGROUND: Although there is a high co-occurrence of psychopathological symptoms and asthma, longitudinal studies considering asthma endotypes in childhood and adolescence are scarce. Therefore, this study examined the prospective association between psychopathology in childhood and current atopic and non-atopic asthma in adolescents, considering sex and puberty-related characteristics. METHODS: The study includes 3584 participants (1790 females, 1794 males) from two German birth cohort studies, GINIplus and LISA. Psychopathological symptoms at age 10 (M = 10.06, SD = .22) were assessed by parent-reported Strengths and Difficulties Questionnaire (SDQ) and current asthma at age 15 (M = 15.07, SD = .30) was defined as a positive parent-reported medical diagnosis, wheezing, and/or medical treatment against asthma (at least two criteria). Atopic asthma was characterized as current asthma and a positive specific immunoglobulin E (IgE) test (≥0.35 kU/L), non-atopic asthma as current asthma without sensitization. Data were analyzed by logistic regression and multinomial regression models, controlling for potential covariates and confounders. RESULTS: Psychopathological symptoms at age 10 were associated with asthma at age 15 (odds ratio (OR) = 1.69, 95% confidence interval (CI) = 1.04-2.92, p = .035). When examining the endotypes, this effect was replicated only for non-atopic asthma at age 15 (relative risk ratio (RRR) = 2.92, 95% CI = 1.13-7.60, p = .028), but not for atopic asthma (p = .381). Regarding the SDQ subscales, an association between peer problems at age 10 and atopic asthma at age 15 was revealed (RRR = 2.00, 95% CI 1.01-3.97, p = .048). Furthermore, significant interaction effects of puberty onset with psychopathological symptoms (p = .020), and particularly with peer problems (p = .029), were found on atopic asthma. CONCLUSION: The findings highlight the importance of early recognition and treatment of psychopathological symptoms to prevent and reduce development, persistence and exacerbation of asthma endotypes, and point to the necessity for further research into hormonal mechanisms linking psychopathology with atopy.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Strengths And Difficulties Questionnaire ; Asthma ; Epidemiology ; Psychopathological Symptoms ; Puberty ; Sex Difference; Difficulties Questionnaire Sdq; Adult-onset Asthma; Behavioral-problems; Incident Asthma; Lung-function; Depression; Strengths; Stress; Children; Risk
ISSN (print) / ISBN 0905-6157
e-ISSN 1399-3038
Journal Pediatric Allergy and Immunology
Quellenangaben Volume: 36, Issue: 7, Pages: 13, Article Number: e70151 Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Grants European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme
Helmholtz Zentrum Munchen
Helmholtz-Centre for Environmental Research - UFZ, Leipzig
Research Institute at Marien-Hospital Wesel
Pediatric Practice, Bad Honnef
Ludwig-Maximilians-Universitat Munchen
Technische Universität München
IUF - Leibniz Research-Institute for Environmental Medicine at the University of Düsseldorf
Federal Ministry for Environment IUF Düsseldorf
Commission of the European Communities
7th Framework Program: MeDALL project
Nestle
Mead Johnson
Federal Ministry for Education, Science, Research and Technology