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Mechanisms and markers of lung ageing in health and disease.
Eur. Respir. Rev. 34, 25:240233 (2025)
Ageing significantly impacts lung function and increases susceptibility to chronic lung diseases. The lung is a complex organ with multiple cell types that undergo cellular age-related perturbations or hallmarks. As knowledge of ageing mechanisms has progressed, we have a better understanding how intracellular adaptations impact cellular crosstalk and integrate to increase the susceptibility to age-related diseases in the lung. Herein, we discuss the prospects of exhaustion of lung progenitor cells, disrupted lung cell plasticity, perturbation in fibroblasts, impaired adaptive immune responses and alterations in lung microenvironment in the promotion of ageing and age-related lung diseases. Additionally, the ageing process trajectory of the lung depends on a combination of biological, genetic, metabolic, biomechanical and sociobehavioural factors that range from protective phenotypes to accelerated ageing phenotypes. We propose the concept of AgEnOmics, which expands the temporal dimension of lung ageing by distinguishing between chronological ageing and accelerated lung ageing phenotypes. Based on this concept, we define biomarkers of biological ageing that will help to define accelerated ageing and early interventions in biological ageing-related lung diseases.
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Publication type
Article: Journal article
Document type
Review
Keywords
Obstructive Pulmonary-disease; Endoplasmic-reticulum Stress; Bronchoalveolar Lavage Fluid; Epithelial-cell Senescence; Growth-factor-i; Endothelial Progenitor Cells; C-reactive Protein; Cigarette-smoke; Dna Methylation; Alveolar Macrophages
ISSN (print) / ISBN
0905-9180
e-ISSN
1600-0617
Journal
European Respiratory Review
Quellenangaben
Volume: 34,
Issue: 177,
Pages: 25,
Article Number: 240233
Publisher
European Respiratory Society
Publishing Place
442 Glossop Rd, Sheffield S10 2px, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Lung Health and Immunity (LHI)
Grants
German Center for Lung Research (DZL)
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Von Behring Rontgen Foundation
NHLBI/NIH
NIH Common Fund, through the Office of Strategic Coordination
Office of the NIH
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
Von Behring Rontgen Foundation
NHLBI/NIH
NIH Common Fund, through the Office of Strategic Coordination
Office of the NIH