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Lauffer, F.* ; Jargosch, M. ; Frey, K.* ; Dadras, M.S.* ; Raunegger, T.* ; Wasserer, S.* ; Schmidt-Weber, C.B. ; Biedermann, T.* ; Eyerich, K.* ; Eyerich, S. ; Traidl-Hoffmann, C. ; Klose, C.* ; Reiger, M. ; Garzorz-Stark, N.*

Skin lipid-microbe interplay links Staphylococcus hominis to barrier control in adult atopic dermatitis.

Allergy, DOI: 10.1111/all.70028 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
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BACKGROUND: Skin surface lipids and commensal microbes are essential for the epidermal barrier, but their mutual interactions remain poorly understood. METHODS: We conducted high-resolution shotgun lipidomics of tape strips from lesional and non-lesional atopic dermatitis (AD) skin and healthy controls. Lipidomic data were integrated with 16S amplicon sequencing to construct lipid-microbe interaction networks. RESULTS: AD skin showed disease-specific lipid-microbe correlations, with less diverse interactions in lesional compared to non-lesional and healthy skin. Staphylococcus hominis (S. hominis) negatively correlated with non-hydroxy-dehydrosphingosine (NdS) 18:0;2/24:0;0 and positively with diacylglycerol (DAG) 18:1;0_18:1;0 and DAG 16:0;0_18:1;0. In vitro co-cultures of reconstructed human epidermis (RHE) with AD skin-derived T cell supernatant (TCS) and S. hominis reduced RHE thickness, spongiosis, and NdS 18:0;2/24:0;0 levels. Furthermore, S. hominis directly lowered NdS 18:0;2/24:0;0 levels in lesional AD skin tape samples, and reversed type 2 inflammation and lipid metabolism gene expression in TCS-stimulated RHE. CONCLUSIONS: These findings identify S. hominis as a key regulator of lipid-microbe interactions in AD, influencing epidermal inflammation and differentiation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Staphylococcus Hominis ; Atopic Dermatitis ; Lipidomics ; Microbiome; Expression
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status Peer reviewed
Institute(s) Institute of Environmental Medicine (IEM)
Institute for Allergy Research (IAF)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Allergy
PSP Element(s) G-503400-001
G-505490-001
G-505400-001
DOI 10.1111/all.70028
WOS ID 001559063900001
Scopus ID 105014606503
PubMed ID 40874637
Erfassungsdatum 2025-10-14
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