PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Palatella, M.* ; Kruse, F.* ; Ji, H. ; Loriani Fard, A.K.* ; Becker, M. ; Daniel, C. ; Rohm, M. ; Huehn, J.*

Acsbg1 maintains intestinal immune homeostasis and controls inflammation by regulating ST2+ Tregs.

Mucosal Immunol., DOI: 10.1016/j.mucimm.2025.10.009 (2025)
Postprint Research data DOI PMC
Open Access Green
The immune balance in mucosal tissues depends on a delicate interplay between inflammatory T helper 17 (Th17) cells and immunosuppressive regulatory T cells (Tregs). But what happens when this balance is disturbed? In this study, we uncovered a critical role for acyl-CoA synthetase bubblegum family member 1 (Acsbg1) in shaping Th17and Treg dynamics. Using Acsbg1-deficient mice, we show that while its absence does not disrupt homeostasis under steady-state conditions, it significantly alters Treg populations, particularly in gut-associated tissues. Under high-fat diet-induced metabolic stress, Acsbg1-deficient mice display mild metabolic changes but maintain systemic immune and metabolic function, indicating that Acsbg1 is dispensable for metabolic adaptation in vivo. However, upon infection with Citrobacter rodentium, these mice exhibit excessive Th1/Th17-driven inflammation and impaired resolution, accompanied by a strong reduction in IL-10-producing and ST2+ Treg subsets. The impact is even more striking in an adoptive transfer colitis model, where Acsbg1-deficient Tregs fail to control inflammation, resulting in severe colitis and tissue damage. Our findings identify Acsbg1 as a key regulator of ST2+ Treg function and a central player in mucosal immune homeostasis, highlighting its potential as a therapeutic target for inflammatory bowel disease and colorectal cancer.
Impact Factor
Scopus SNIP
Altmetric
0.000
0.000
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Acsbg1 ; Colitis ; Fatty Acid Metabolism ; Mucosal Immunology ; Th17 Cell ; Tregs
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 1933-0219
e-ISSN 1933-0219
Journal Mucosal Immunology
Publisher Nature Publishing Group
Publishing Place UNITED STATES
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
Research Unit Type 1 Diabetes Immunology (TDI)
POF-Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-501900-251
G-502191-001
G-501900-257
DOI 10.1016/j.mucimm.2025.10.009
Scopus ID 105020696881
PubMed ID 41151718
Erfassungsdatum 2025-10-30
[➜Report correction]