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Linkohr, B. ; Heier, M. ; Gieger, C. ; Thorand, B. ; Grallert, H. ; Holle, R.* ; Karrasch, S. ; Koenig, W.* ; Ladwig, K.H.* ; Laxy, M.* ; Lorenz-Depiereux, B. ; Rospleszcz, S. ; Schneider, A.E. ; Schulz, H. ; Schwettmann, L. ; Standl, M. ; Waldenberger, M. ; Wang-Sattler, R. ; Wolf, K. ; Dallavalle, M. ; Rückert-Eheberg, I.-M. ; Schneider, A. ; Leidl, R. ; Wichmann, H.-E. ; Peters, A.

Cohort profile: Cooperative health research in the region of Augsburg (KORA) 1984-2024.

Int. J. Epidemiol. 54:dyaf187 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
The KORA study (Cooperative Health Research in the Region of Augsburg) is a German population-based prospective cohort study investigating risk factors, early detection, and prevention of chronic diseases. KORA focuses on cardiovascular disease, diabetes, mental health, health in old age, lung health, and the role of social determinants and environmental exposures.The KORA study recruited 17 602 adult participants aged 25–74 years in four baseline surveys conducted between 1984 and 2001 in the Region of Augsburg, Germany.It includes up to 40 years of active follow-up for the initial participants and is ongoing to date. In 2021, of the initial 17 602 participants, 6493 participants were deceased and 2000 participants were lost to follow-up.Besides morbidity and mortality follow-ups, repeated follow-up examinations were conducted in subpopulations with questionnaire-based risk factor and socio-economic assessments. Genetic and molecular phenotyping contributed to identifying the underlying genomic, epigenomic, transcriptomic, proteomic, and metabolomic signatures of non-communicable diseases. Furthermore, the study is enriched by detailed environmental data at the place of residence and the establishment of a unique air-pollution measurement station.Data and biosamples can be requested for research projects via the KORA.PASST use and access hub (https://helmholtz-muenchen.managed-otrs.com/external).
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Publication type Article: Journal article
Document type Scientific Article
Keywords Ageing ; Environmental Exposure ; Genomics ; Non-communicable Diseases ; Prospective Studies ; Risk Factors; Coronary-heart-disease; C-reactive Protein; Population; Inflammation; Association; Prevalence; Prediction; Trends; Men
ISSN (print) / ISBN 0300-5771
e-ISSN 1464-3685
Journal International Journal of Epidemiology
Quellenangaben Volume: 54, Issue: 6, Pages: , Article Number: dyaf187 Supplement: ,
Publisher Oxford University Press
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Health Economics and Health Care Management (IGM)
Institute of Translational Genomics (ITG)
Grants German Federal Ministry of Education and Research