PuSH - Publication Server of Helmholtz Zentrum München: Dynamics of postnatal upper airway bacteria colonization in preterm infants <1000g and bronchopulmonary dysplasia.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Frodermann, T.* ; Rochwalsky, U.* ; Selting, A.* ; Oehmke, F.* ; Gentil, K.* ; Kempf, V.A.J.* ; Göttig, S.* ; Hogardt, M.* ; Anagnostou, A.* ; Schloter, M. ; Staude, B.* ; Gertheiss, J.* ; Ehrhardt, H.*

Dynamics of postnatal upper airway bacteria colonization in preterm infants <1000g and bronchopulmonary dysplasia.

Sci. Rep. 15:42558 (2025)

Publ. Version/Full Text

Research data

DOI

PMC

	Open Access Gold

Abstract
Metrics
Extra information

Aberrant microbial colonization of premature infants is increasingly recognized as a risk factor for severe acute morbidities. The aim of this study was to evaluate the correlation of bacterial upper airway colonization within the first 6 weeks of life in preterm infants <1000g and risk of moderate/severe bronchopulmonary dysplasia (BPD). In this retrospective two-center cohort study postnatal upper airway bacterial colonization of premature infants with a birth weight <1000g was analyzed. Bacteria were categorized into facultative- and highly pathogenic. Within 242 infants, a birth weight cutoff of 800g prevailed as the most relevant discriminator for risk of BPD. Furthermore, center, male sex, duration of antibiotic therapy, and delayed detection of facultative pathogenic bacteria after week 4 was associated with the development of BPD. Using classification tree analyses for the binary outcome, antibiotic therapy was more importance in infants <800g, whereas in those with a birth weight ≥800g, delayed colonization with facultative pathogenic bacteria was more relevant than antibiotic exposure. We add delayed colonization of the upper airway with facultative pathogenic bacteria to the risks for BPD. The variations of microbial colonization should be considered in future studies on the pathogenesis of BPD and new treatment modalities.

Impact Factor

Scopus SNIP

Altmetric

3.900

0.000