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Performance of stenting in femoropopliteal disease: A systematic literature review and meta-analysis of proportions.
J. Comparative Effectiveness Res. 15:e250152 (2026)
Aim: To evaluate the performance of four stent types (BMS, bare metal stents; Eluvia, a polymer-based paclitaxel-eluting stent; Viabahn, a covered stent; and Zilver PTX, a polymer-free paclitaxel-coated stent) in femoropopliteal lesions at 12 and 24 months using a meta-analysis of proportions. Materials & methods: This systematic review (PROSPERO CRD42024528559) used PubMed to identify relevant single-arm and comparative studies (with ≥50 patients/study) published between 1 January 2009 and 1 July 2024. Data on patient/lesion characteristics and outcomes were extracted. Subgroup analyses were based on lesion length (<150 mm vs ≥150 mm) and study quality. A random-intercept logistic regression model was used to pool the data. The 95% CI around the pooled effect was calculated using Knapp-Hartung adjustments. Results: Data were extracted from 141 of the 870 screened studies, corresponding to 35,897 patients. The mean patient age was 70.9 (range: 63.3-80.0) years; 69.6% were male. The overall mean lesion length was 153.1 (range: 37-330) mm. Although all stent types performed well in the main analysis, Eluvia exhibited consistently high primary patency and low target lesion revascularization rates at both timepoints and across lesion lengths. Mortality rates for all stent types were stable for short lesions but more variable for long lesions. Conclusion: All stents used in short lesions performed well; however, Eluvia also demonstrated reliable performance in long lesions.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Drug-eluting Stent ; Femoropopliteal Artery ; Paclitaxel ; Peripheral Arterial Disease ; Pooled Rates ; Primary Patency ; Target Lesion Revascularization; Superficial Femoral-artery; Drug-eluting Stent; Bare-metal Stents; Interwoven Nitinol Stent; Proximal Popliteal Arteries; Vs. Balloon Angioplasty; Critical Limb Ischemia; Self-expanding Stents; Long-term Outcomes; Zilver Ptx
ISSN (print) / ISBN
2042-6305
e-ISSN
2042-6313
Quellenangaben
Volume: 15,
Issue: 4,
Article Number: e250152
Publisher
Becaris Publishing Ltd
Publishing Place
43 Kneesworth Street, Royston, United Kingdom
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
Boston Scientific (MA, USA)