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Third generation genome sequencing of the endobacterium Corynebacterium kroppenstedtii subsp. demodicis reveals details of its microbe-host-Interaction with the most complex human commensal, Demodex folliculorum.
Environ. Microbiol. Rep. 18:e70374 (2026)
Demodex mites inhabit the pilosebaceous unit despite harsh environmental conditions including UV radiation, variable salinity, and cosmetics. Their recently characterized endobacterium may contribute to this resilience. This study aimed to elucidate mechanisms of the microbe-host interaction that help mites withstand environmental stress. The genome of Corynebacterium kroppenstedtii subsp. demodicis was sequenced using PacBio technology and annotated via MicroScope. Metabolic and symbiotic traits were analyzed using KEGG and compared with the Demodex folliculorum secretome from published transcriptome data. The complete 2,456,075 bp genome contains 2034 coding sequences and exhibits reduced variable genes compared to other Corynebacterium species. Primary metabolism comprises an almost complete minimal gene set but lacks two tRNA synthetases and genes for phosphatidylethanolamine and NAD+ biosynthesis. Carbohydrate pathways are incomplete and fatty acid synthase I is absent. Secondary metabolism includes complete mevalonate and β-carotene biosynthetic pathways, while the methylerythritol phosphate pathway is missing. UV protection and oxidative stress tolerance are supported by β-carotene, ClpB, RecN, MsrA, KatA, SodA, and manganese transporter SitB. The secretome contains hydrolases likely aiding mite digestion. These findings provide genomic insights into mite-bacterium symbiosis and follicular adaptation. All functional inferences are based on genomic data and in silico predictions; experimental validation remains to be established.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Demodicidae ; Endosymbiont ; Mite ; Parasite ; Symbiosis; Database; Kegg
ISSN (print) / ISBN
1758-2229
e-ISSN
1758-2229
Quellenangaben
Volume: 18,
Issue: 3,
Article Number: e70374
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Reviewing status
Peer reviewed
Institute(s)
Research Unit Comparative Microbiome Analysis (COMI)
Grants
Medical & Clinician Scientist Program (MCSP) at LMU Munich