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Post-diagnosis physical activity in relation to mortality among prostate cancer survivors: A systematic review and meta-analysis.
Cancer Causes Control 37:108 (2026)
BACKGROUND: Physical activity after cancer diagnosis may reduce mortality. However, systematic evidence for this association for men living with prostate cancer remains limited. METHODS: We searched PubMed, Embase, and CINAHL data bases from start to June 2025. Random-effects meta-analyses estimated summary hazard ratios (HRs) and 95% confidence intervals (CI) for all-cause mortality and prostate-cancer-specific mortality to assess the association between post-diagnosis physical activity, measured in metabolic equivalents of task-hours per week (MET-hr/week), and mortality among prostate cancer survivors. RESULTS: We included ten studies with more than 50,144 participants (one study did not report the number of prostate cancer cases included in the meta-analysis) and 28,044 deaths. Higher levels of post-diagnosis physical activity (≥ 7.5 MET-hr/week) were associated with lower all-cause mortality (HR = 0.69; 95% CI: 0.62-0.77), compared to lower levels (< 7.5 MET-hr/week). Meta-analysis of five studies showed an inverse association between post-diagnosis physical activity and prostate cancer-specific mortality (HR = 0.77; 95% CI: 0.66-0.89). Meta-analysis of four studies showed that moderate-to-vigorous physical activity was inversely associated with mortality (HR = 0.62; 95% CI: 0.51-0.74). CONCLUSION: Higher post-diagnosis physical activity, including activity at higher intensities, was associated with lower all-cause and prostate cancer-specific mortality among men living with prostate cancer. Our findings suggest that physical activity may complement cancer care for prostate cancer patients.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Meta-analysis ; Mortality ; Post-diagnosis Physical Activity ; Prostate Cancer Survivors; Exercise; Men
ISSN (print) / ISBN
0957-5243
e-ISSN
1573-7225
Journal
Cancer Causes & Control
Quellenangaben
Volume: 37,
Issue: 7,
Article Number: 108
Publisher
Springer
Publishing Place
Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
Grants
Universitt Regensburg (3161)