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Post-diagnosis physical activity in relation to mortality among gynecological cancer survivors.
Cancer Causes Control 37:121 (2026)
PURPOSE: Physical activity may play a supportive role in cancer survivorship. However, evidence on the association between post-diagnosis physical activity and mortality among women with gynecological cancer remains limited and inconsistent. METHODS: We conducted a systematic review of the literature published between 1949 and January 2026. Eligible observational studies were identified, and random-effects meta-analyses were performed to estimate pooled hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between post-diagnosis physical activity and all-cause mortality among women diagnosed with gynecological cancer. RESULTS: A total of ten eligible studies on endometrial, ovarian, and cervical cancer were included, collectively reporting 3,867 deaths. High levels of post-diagnosis physical activity, compared with low levels, were associated with lower mortality (HR: 0.65; 95% CI 0.54-0.78). This inverse relationship was evident in both endometrial and ovarian cancer survivors (endometrial cancer: HR: 0.60; 95% CI 0.43-0.83; ovarian cancer: HR: 0.71; 95% CI 0.58-0.86). Medium levels of physical activity tended to be inversely associated with mortality (HR: 0.88; 95% CI 0.76-1.02). CONCLUSION: Higher levels of physical activity after a gynecological cancer diagnosis were associated with improved survival. The results suggest that physical activity may represent a modifiable lifestyle factor with the potential to improve long-term outcomes among gynecological cancer survivors. IMPLICATIONS FOR CANCER SURVIVORS: This supports the potential value of integrating physical activity into survivorship care, although further high-quality prospective studies are needed to strengthen causal inference.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Endometrial Cancer ; Survivorship Curve ; Cervical Cancer ; Physical Activity ; Ovarian Cancer ; Cancer ; Observational Study ; Prospective Cohort Study ; Hazard Ratio; Women; Barriers; Health; Risk
ISSN (print) / ISBN
0957-5243
e-ISSN
1573-7225
Journal
Cancer Causes & Control
Quellenangaben
Volume: 37,
Issue: 8,
Article Number: 121
Publisher
Springer
Publishing Place
Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
Grants
Universittsklinikum Regensburg (8921)